Differential levels of circulating progenitor cells in acute coronary syndrome patients with a first event versus patients with recurring events

Italo Porto, Ilaria Dato, Luca Di Vito, Giovanni L. De Maria, Alessandra Tritarelli, Antonio M. Leone, Alessandra Paglia, Maurizio C. Capogrossi, Luigi M. Biasucci, Filippo Crea

Research output: Contribution to journalArticle

Abstract

Objective: Pathophysiology of acute coronary syndromes in patients presenting with a first cardiac event (FCE) can be different from patients with a recurring cardiac event (RCE). We assessed inflammatory activation and circulating progenitor cells' (CPC) mobilisation in patients with a FCE versus those with RCE. Methods: We recruited 41 patients: 18 with FCE and 23 with RCE. Peripheral blood samples were drawn at baseline and at 20 days to measure high sensitivity C-reactive protein (CRP) and to assess CD34+/133+ CPC and CD34+/KDR+ CPC by flow cytometry. Results: CD34+/133+ cells (% number of cells per total number of cytometric events) were similar at baseline, being 0.25% (0.17-0.42%) in the FCE vs 0.23% (0.11-0.43%) in the RCE group, and increased at follow-up only in the FCE group to 0.41% (0.22-0.64%), while in the RCE group they were 0.27% (0.11-0.36%) (p = 0.009 for the interaction, p = 0.07 for the main effect of time). CD34+/KDR+ cells were similar at baseline in the two groups, did not significantly increase over time (p = 0.2), and no differential effect of FCE vs RCE over time was seen (p = 0.38). CRP levels, similar at baseline, were consistently reduced at 20 days after ACS (p = 0.001), with no differential effect of FCE vs RCE pts (p = 0.74). Variation from baseline to follow-up for both CD34+/133+ and CD34+/KDR+ did not correlate with either baseline CRP or delta CRP. Conclusions: Our data demonstrate a differential CPC mobilization behavior for FCE patients compared to RCE ones, independent of inflammatory activation.

Original languageEnglish
Pages (from-to)50-54
Number of pages5
JournalInternational Journal of Cardiology
Volume149
Issue number1
DOIs
Publication statusPublished - May 19 2011

Keywords

  • Acute coronary syndrome
  • Bone marrow
  • C-reactive protein
  • Circulating progenitor cells

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Porto, I., Dato, I., Di Vito, L., De Maria, G. L., Tritarelli, A., Leone, A. M., Paglia, A., Capogrossi, M. C., Biasucci, L. M., & Crea, F. (2011). Differential levels of circulating progenitor cells in acute coronary syndrome patients with a first event versus patients with recurring events. International Journal of Cardiology, 149(1), 50-54. https://doi.org/10.1016/j.ijcard.2009.11.039