Differential modulation of invertebrate hemocyte motility by CRF, ACTH, and its fragments

Susanna Genedani, Mara Bernardi, Enzo Ottaviani, Claudio Franceschi, Michael K. Leung, George B. Stefano

Research output: Contribution to journalArticlepeer-review


Various reports have shown that invertebrate hemocytes are responsive to mammalian neuropeptides and cytokines. In the present study, we demonstrate that corticotropin-releasing factor (CRF) and adrenocorticotropin (ACTH) fragments (1-24), (1-4), (4-9), (1-13), (1-17), and (11-24) significantly stimulate molluscan hemocyte migration, and the whole sequence (1-39) and the fragment (4-11) have an inhibitory effect. Differences between species were found with respect to the response to individual fragments. Additionally, the (4-11) fragment was able to antagonize some of the stimulatory fragments (4-9) as well as tumor necrosis factor (TNF-α)-induced chemotaxis. Our results suggest that invertebrate hemocytes are able to respond to CRF and ACTH fragments that in turn provide further evidence of the complexity of intercellular signaling within the immune system in relatively primitive animals. Thus, auto- and neuroimmunoregulatory activities in mammals must have had an earlier beginning than previously believed.

Original languageEnglish
Pages (from-to)203-206
Number of pages4
Issue number2
Publication statusPublished - 1994


  • ACTH fragments
  • CRF
  • Hemocyte migration
  • Molluscs

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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