Differential postnatal development of mu-, delta- and kappa-opioid binding sites in rat brain.

P. Petrillo, A. Tavani, D. Verotta, L. E. Robson, H. W. Kosterlitz

Research output: Contribution to journalArticle

Abstract

With selective labelling techniques and analysis of saturation curves it is shown that in rat brain the concentrations of mu-, delta- and kappa-binding sites increase differentially during postnatal development. There are no changes in the binding affinities. The concentration (pmol/g brain) of kappa-sites are first to reach adult levels, namely between 7 and 14 days after birth. Adult levels of mu-sites are attained between 14 and 21 days after birth. The most striking finding is that development of delta-sites, which are not detectable 3 days after birth by the method used, lags markedly behind that of mu- and kappa-sites. The profile of development in rat brain is compared to that found previously in mouse brain.

Original languageEnglish
Pages (from-to)53-58
Number of pages6
JournalBrain Research
Volume428
Issue number1
Publication statusPublished - Jan 1987

ASJC Scopus subject areas

  • Neuroscience(all)

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    Petrillo, P., Tavani, A., Verotta, D., Robson, L. E., & Kosterlitz, H. W. (1987). Differential postnatal development of mu-, delta- and kappa-opioid binding sites in rat brain. Brain Research, 428(1), 53-58.