Differential proteomic analysis of hepatocellular carcinoma

Giuseppe Corona, Elisa De Lorenzo, Caterina Elia, Maria Paola Simula, Claudio Avellini, Umberto Baccarani, Francesco Lupo, Claudio Tiribelli, Alfonso Colombatti, Giuseppe Toffoli

Research output: Contribution to journalArticle

Abstract

The principal aim of the present study consisted in the identification of the disregulated proteins associated with the development of hepatocellular carcinoma (HCC). The differences in protein expression between hepatocellular carcinoma (HCC) and the corresponding non-HCC liver tissues were investigated in a cohort of 20 patients using two-dimensional fluorescence difference in gel electrophoresis (2D-DIGE) coupled with mass spectrometry (MS). The up-and down-regulated protein spots that exhibited 1.5-fold difference signal intensity with statistical significance (p

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalInternational Journal of Oncology
Volume36
Issue number1
DOIs
Publication statusPublished - Jan 2010

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Keywords

  • Aldo-keto reductase 1C2
  • Biomarkers
  • Carcinoma
  • Hepatocellular
  • Thioredoxin
  • Transketolase

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Corona, G., De Lorenzo, E., Elia, C., Simula, M. P., Avellini, C., Baccarani, U., Lupo, F., Tiribelli, C., Colombatti, A., & Toffoli, G. (2010). Differential proteomic analysis of hepatocellular carcinoma. International Journal of Oncology, 36(1), 93-99. https://doi.org/10.3892/ijo-00000479