Differential pulse polarographic determination of BCNU pharmacokinetics in patients with lung cancer

R. Russo, I. Bartosek, E. Piazza, A. M. Santi, A. Libretti, S. Garattini

Research output: Contribution to journalArticle

Abstract

BCNU levels were determined by differential pulse polarography in 12 patients with lung cancer. A simple assay method for submicrogram quantities of nitrosoureas is described. The half-life of BCNU added to plasma in vitro was 1413 mins at 0°C and 12 mins at 37°C during incubation. BCNU kinetics in blood of treated patients was calculated using the two-compartment open model; the half-life of the drug was 1.4 mins in the first phase and 17.8 mins in the second. Mean distribution volume was 2.59 liters/kg and plasma clearance was 16.7 ml/min/kg.

Original languageEnglish
Pages (from-to)555-562
Number of pages8
JournalCancer Treatment Reports
Volume65
Issue number7-8
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Differential pulse polarographic determination of BCNU pharmacokinetics in patients with lung cancer'. Together they form a unique fingerprint.

Cite this