Abstract
BCNU levels were determined by differential pulse polarography in 12 patients with lung cancer. A simple assay method for submicrogram quantities of nitrosoureas is described. The half-life of BCNU added to plasma in vitro was 1413 mins at 0°C and 12 mins at 37°C during incubation. BCNU kinetics in blood of treated patients was calculated using the two-compartment open model; the half-life of the drug was 1.4 mins in the first phase and 17.8 mins in the second. Mean distribution volume was 2.59 liters/kg and plasma clearance was 16.7 ml/min/kg.
| Original language | English |
|---|---|
| Pages (from-to) | 555-562 |
| Number of pages | 8 |
| Journal | Cancer Treatment Reports |
| Volume | 65 |
| Issue number | 7-8 |
| Publication status | Published - 1981 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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Differential pulse polarographic determination of BCNU pharmacokinetics in patients with lung cancer. / Russo, R.; Bartosek, I.; Piazza, E.; Santi, A. M.; Libretti, A.; Garattini, S.
In: Cancer Treatment Reports, Vol. 65, No. 7-8, 1981, p. 555-562.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differential pulse polarographic determination of BCNU pharmacokinetics in patients with lung cancer
AU - Russo, R.
AU - Bartosek, I.
AU - Piazza, E.
AU - Santi, A. M.
AU - Libretti, A.
AU - Garattini, S.
PY - 1981
Y1 - 1981
N2 - BCNU levels were determined by differential pulse polarography in 12 patients with lung cancer. A simple assay method for submicrogram quantities of nitrosoureas is described. The half-life of BCNU added to plasma in vitro was 1413 mins at 0°C and 12 mins at 37°C during incubation. BCNU kinetics in blood of treated patients was calculated using the two-compartment open model; the half-life of the drug was 1.4 mins in the first phase and 17.8 mins in the second. Mean distribution volume was 2.59 liters/kg and plasma clearance was 16.7 ml/min/kg.
AB - BCNU levels were determined by differential pulse polarography in 12 patients with lung cancer. A simple assay method for submicrogram quantities of nitrosoureas is described. The half-life of BCNU added to plasma in vitro was 1413 mins at 0°C and 12 mins at 37°C during incubation. BCNU kinetics in blood of treated patients was calculated using the two-compartment open model; the half-life of the drug was 1.4 mins in the first phase and 17.8 mins in the second. Mean distribution volume was 2.59 liters/kg and plasma clearance was 16.7 ml/min/kg.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019425444&partnerID=8YFLogxK
M3 - Article
C2 - 7248980
AN - SCOPUS:0019425444
VL - 65
SP - 555
EP - 562
JO - Cancer Treatment Reports
JF - Cancer Treatment Reports
SN - 0361-5960
IS - 7-8
ER -