Abstract
BCNU levels were determined by differential pulse polarography in 12 patients with lung cancer. A simple assay method for submicrogram quantities of nitrosoureas is described. The half-life of BCNU added to plasma in vitro was 1413 mins at 0°C and 12 mins at 37°C during incubation. BCNU kinetics in blood of treated patients was calculated using the two-compartment open model; the half-life of the drug was 1.4 mins in the first phase and 17.8 mins in the second. Mean distribution volume was 2.59 liters/kg and plasma clearance was 16.7 ml/min/kg.
| Original language | English |
|---|---|
| Pages (from-to) | 555-562 |
| Number of pages | 8 |
| Journal | Cancer Treatment Reports |
| Volume | 65 |
| Issue number | 7-8 |
| Publication status | Published - 1981 |
ASJC Scopus subject areas
- Cancer Research
- Oncology