Differential pulse polarographic determination of BCNU pharmacokinetics in patients with lung cancer

R. Russo, I. Bartosek, E. Piazza, A. M. Santi, A. Libretti, S. Garattini

Research output: Contribution to journalArticle

Abstract

BCNU levels were determined by differential pulse polarography in 12 patients with lung cancer. A simple assay method for submicrogram quantities of nitrosoureas is described. The half-life of BCNU added to plasma in vitro was 1413 mins at 0°C and 12 mins at 37°C during incubation. BCNU kinetics in blood of treated patients was calculated using the two-compartment open model; the half-life of the drug was 1.4 mins in the first phase and 17.8 mins in the second. Mean distribution volume was 2.59 liters/kg and plasma clearance was 16.7 ml/min/kg.

Original languageEnglish
Pages (from-to)555-562
Number of pages8
JournalCancer Treatment Reports
Volume65
Issue number7-8
Publication statusPublished - 1981

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Carmustine
Lung Neoplasms
Pharmacokinetics
Half-Life
Polarography
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Russo, R., Bartosek, I., Piazza, E., Santi, A. M., Libretti, A., & Garattini, S. (1981). Differential pulse polarographic determination of BCNU pharmacokinetics in patients with lung cancer. Cancer Treatment Reports, 65(7-8), 555-562.

Differential pulse polarographic determination of BCNU pharmacokinetics in patients with lung cancer. / Russo, R.; Bartosek, I.; Piazza, E.; Santi, A. M.; Libretti, A.; Garattini, S.

In: Cancer Treatment Reports, Vol. 65, No. 7-8, 1981, p. 555-562.

Research output: Contribution to journalArticle

Russo, R, Bartosek, I, Piazza, E, Santi, AM, Libretti, A & Garattini, S 1981, 'Differential pulse polarographic determination of BCNU pharmacokinetics in patients with lung cancer', Cancer Treatment Reports, vol. 65, no. 7-8, pp. 555-562.
Russo, R. ; Bartosek, I. ; Piazza, E. ; Santi, A. M. ; Libretti, A. ; Garattini, S. / Differential pulse polarographic determination of BCNU pharmacokinetics in patients with lung cancer. In: Cancer Treatment Reports. 1981 ; Vol. 65, No. 7-8. pp. 555-562.
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