Differential radiosensitivity in cultured B-16 melanoma cells following interrupted melanogenesis induced by glucosamine.

A. M. Mileo, E. Mattei, M. Fanuele, A. Delpino, U. Ferrini

Research output: Contribution to journalArticle

Abstract

The relationship between cell pigmentation and radiosensitivity was investigated in a cell model in which melanogenesis was suppressed by a glycosylation inhibitor. It was found that X-irradiation of melanotic B-16 melanoma cells and their amelanotic counterparts, obtained by glucosamine treatment, showed an inverse correlation between radiosensitivity and melanin contents. Since melanogenesis interruption by glucosamine does not affect the DNA repair capacity of nonpigmented cells, it is likely that intracellular melanins play a role in the relative resistance of pigmented cells to X-irradiation.

Original languageEnglish
Pages (from-to)167-170
Number of pages4
JournalPigment Cell Research
Volume2
Issue number3
Publication statusPublished - May 1989

Fingerprint

melanogenesis
glucosamine
Radiation Tolerance
Glucosamine
Melanins
melanoma
Melanoma
Irradiation
Glycosylation
melanin
Repair
cells
irradiation
DNA
Pigmentation
glycosylation
DNA repair
DNA Repair
pigmentation

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Plant Science
  • Cell Biology
  • Clinical Biochemistry
  • Developmental Biology

Cite this

Differential radiosensitivity in cultured B-16 melanoma cells following interrupted melanogenesis induced by glucosamine. / Mileo, A. M.; Mattei, E.; Fanuele, M.; Delpino, A.; Ferrini, U.

In: Pigment Cell Research, Vol. 2, No. 3, 05.1989, p. 167-170.

Research output: Contribution to journalArticle

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