Differential radiosensitivity in cultured B-16 melanoma cells following interrupted melanogenesis induced by glucosamine.

A. M. Mileo, E. Mattei, M. Fanuele, A. Delpino, U. Ferrini

Research output: Contribution to journalArticlepeer-review

Abstract

The relationship between cell pigmentation and radiosensitivity was investigated in a cell model in which melanogenesis was suppressed by a glycosylation inhibitor. It was found that X-irradiation of melanotic B-16 melanoma cells and their amelanotic counterparts, obtained by glucosamine treatment, showed an inverse correlation between radiosensitivity and melanin contents. Since melanogenesis interruption by glucosamine does not affect the DNA repair capacity of nonpigmented cells, it is likely that intracellular melanins play a role in the relative resistance of pigmented cells to X-irradiation.

Original languageEnglish
Pages (from-to)167-170
Number of pages4
JournalPigment Cell Research
Volume2
Issue number3
Publication statusPublished - May 1989

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Plant Science
  • Cell Biology
  • Clinical Biochemistry
  • Developmental Biology

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