Differential regulation of neurexin at glutamatergic and GABAergic synapses

Giulia Pregno, Elena Frola, Stefania Graziano, Annarita Patrizi, Federico Bussolino, Marco Arese, Marco Sassoè-Pognetto

Research output: Contribution to journalArticlepeer-review

Abstract

Neurexins (Nrxs) have emerged as potential determinants of synaptic specificity, but little is known about their localization at central synapses. Here we show that Nrxs have a remarkably selective localization at distinct types of glutamatergic synapses and we reveal an unexpected ontogenetic regulation of Nrx expression at GABAergic synapses. Our data indicate that synapses are specified by molecular interactions that involve both Nrx-dependent and Nrx-independent mechanisms. We propose that differences in the spatio-temporal profile of Nrx expression may contribute to specify the molecular identity of synapses.

Original languageEnglish
JournalFrontiers in Cellular Neuroscience
Issue numberAPR
DOIs
Publication statusPublished - Apr 4 2013

Keywords

  • Cerebellum
  • GABA receptor
  • Neurexin
  • Neuroligin
  • Synapticspecificity

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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