TY - JOUR
T1 - Differential response of the human hepatoma-derived cell line HA22T/VGH to polypeptide mitogens
AU - Clementi, Massimo
AU - Testa, Ivano
AU - Festa, Antonella
AU - Bagnarelli, Patrizia
AU - Chang, Chungming
AU - Carloni, Guido
PY - 1987/8/31
Y1 - 1987/8/31
N2 - Several human cell lines derived from primary cancer of the liver are able to grow under serum-free conditions and produce spreading and growth factors which are released into the culture medium. Since this autocrine growth under hormone-free conditions might play a basic role in malignant transformation, we studied the effect on cell replication and the presence of specific membrane receptors of epidermal growth factor (EGF) and insulin on a dedifferentiated human hepatoma cell line, named HA22T/VGH. Our results point to a similar inhibitory effect on cell replication in the presence of both EGF and insulin, in spite of detecting different affinities of binding.
AB - Several human cell lines derived from primary cancer of the liver are able to grow under serum-free conditions and produce spreading and growth factors which are released into the culture medium. Since this autocrine growth under hormone-free conditions might play a basic role in malignant transformation, we studied the effect on cell replication and the presence of specific membrane receptors of epidermal growth factor (EGF) and insulin on a dedifferentiated human hepatoma cell line, named HA22T/VGH. Our results point to a similar inhibitory effect on cell replication in the presence of both EGF and insulin, in spite of detecting different affinities of binding.
KW - (Human hepatoma cell line)
KW - Epidermal growth factor receptor
KW - Hepatitis B virus
KW - Insulin receptor
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U2 - 10.1016/0014-5793(87)80343-5
DO - 10.1016/0014-5793(87)80343-5
M3 - Article
C2 - 3040466
AN - SCOPUS:0023223709
VL - 221
SP - 11
EP - 17
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 1
ER -