Differential response of the human hepatoma-derived cell line HA22T/VGH to polypeptide mitogens

Massimo Clementi, Ivano Testa, Antonella Festa, Patrizia Bagnarelli, Chungming Chang, Guido Carloni

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Several human cell lines derived from primary cancer of the liver are able to grow under serum-free conditions and produce spreading and growth factors which are released into the culture medium. Since this autocrine growth under hormone-free conditions might play a basic role in malignant transformation, we studied the effect on cell replication and the presence of specific membrane receptors of epidermal growth factor (EGF) and insulin on a dedifferentiated human hepatoma cell line, named HA22T/VGH. Our results point to a similar inhibitory effect on cell replication in the presence of both EGF and insulin, in spite of detecting different affinities of binding.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalFEBS Letters
Volume221
Issue number1
DOIs
Publication statusPublished - Aug 31 1987

Fingerprint

hyaluronate lyase
Mitogens
Hepatocellular Carcinoma
Cells
Insulin
Cell Line
Peptides
Liver Neoplasms
Epidermal Growth Factor
Liver
Growth Hormone
Culture Media
Intercellular Signaling Peptides and Proteins
Hormones
Membranes
Serum
ErbB Receptors

Keywords

  • (Human hepatoma cell line)
  • Epidermal growth factor receptor
  • Hepatitis B virus
  • Insulin receptor

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Differential response of the human hepatoma-derived cell line HA22T/VGH to polypeptide mitogens. / Clementi, Massimo; Testa, Ivano; Festa, Antonella; Bagnarelli, Patrizia; Chang, Chungming; Carloni, Guido.

In: FEBS Letters, Vol. 221, No. 1, 31.08.1987, p. 11-17.

Research output: Contribution to journalArticle

Clementi, Massimo ; Testa, Ivano ; Festa, Antonella ; Bagnarelli, Patrizia ; Chang, Chungming ; Carloni, Guido. / Differential response of the human hepatoma-derived cell line HA22T/VGH to polypeptide mitogens. In: FEBS Letters. 1987 ; Vol. 221, No. 1. pp. 11-17.
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