Differential response of the human hepatoma-derived cell line HA22T/VGH to polypeptide mitogens

Massimo Clementi, Ivano Testa, Antonella Festa, Patrizia Bagnarelli, Chungming Chang, Guido Carloni

Research output: Contribution to journalArticle

Abstract

Several human cell lines derived from primary cancer of the liver are able to grow under serum-free conditions and produce spreading and growth factors which are released into the culture medium. Since this autocrine growth under hormone-free conditions might play a basic role in malignant transformation, we studied the effect on cell replication and the presence of specific membrane receptors of epidermal growth factor (EGF) and insulin on a dedifferentiated human hepatoma cell line, named HA22T/VGH. Our results point to a similar inhibitory effect on cell replication in the presence of both EGF and insulin, in spite of detecting different affinities of binding.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalFEBS Letters
Volume221
Issue number1
DOIs
Publication statusPublished - Aug 31 1987

Keywords

  • (Human hepatoma cell line)
  • Epidermal growth factor receptor
  • Hepatitis B virus
  • Insulin receptor

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Fingerprint Dive into the research topics of 'Differential response of the human hepatoma-derived cell line HA22T/VGH to polypeptide mitogens'. Together they form a unique fingerprint.

Cite this