Differential salicylate-aspirin interaction on vascular prostacyclin and platelet thromboxane synthesis in patients undergoing saphenectomy

E. Dejana, V. Costantini, G. de Amicis, C. Cerletti, G. Lorenzi, G. de Gaetano

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the ability of salicylate to counteract the effect of aspirin on platelet thromboxane synthesis and prostacyclin formation in venous tissue in patients undergoing saphenectomy. A single intravenous dose of 40 mg aspirin completely blocked thromboxane formation and reduced prostacyclin to about 43% of the control values. When salicylate (1000 mg po) corresponding in anesthetized subjects to blood levels of 25.9 ± 5 μg/ml was administered before aspirin, vascular prostacyclin was no longer inhibited, whereas platelet thromboxane was still significantly blocked. These results suggest that the combination of salicylate with aspirin at an appropriate dose ratio may result in almost complete dissociation of the drug's effect on platelets and vessels in man.

Original languageEnglish
Pages (from-to)533-537
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume180
Issue number3
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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