Differential sensitivity of selected rat brain areas to excitatory neurotransmitters released by K+ depolarization

Alberto Luini, Ora Goldberg, Vivian I. Teichberg

Research output: Contribution to journalArticlepeer-review

Abstract

The depolarization of brain slices by high K+ concentrations in the presence of Ca2+ ions leads to the release from nerve terminals of endogenous excitatory neurotransmitters that interact with subsynaptic receptors controlling the neuronal membrane permeability to Na+ ions. This interaction has been studied by following the K+-evoked Ca2+-dependent 22Na+ efflux from 22Na+-preloaded slices from the cortex, striatum, hippocampus, cerebellum, substantia nigra and hypothalamus of the rat. The results indicate that the so-called N-methyl-d-aspartate receptor mediates the bulk of the excitatory transactions in the cortex and striatum whereas a subsynaptic glutamate receptor may mediate those in the hippocampus and cerebellum.

Original languageEnglish
Pages (from-to)325-330
Number of pages6
JournalNeuroscience Letters
Volume49
Issue number3
DOIs
Publication statusPublished - Aug 31 1984

Keywords

  • brain
  • distribution
  • excitatory amino acids
  • rat
  • subsynaptic receptors

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Differential sensitivity of selected rat brain areas to excitatory neurotransmitters released by K+ depolarization'. Together they form a unique fingerprint.

Cite this