TY - JOUR
T1 - Differential sensitivity of selected rat brain areas to excitatory neurotransmitters released by K+ depolarization
AU - Luini, Alberto
AU - Goldberg, Ora
AU - Teichberg, Vivian I.
PY - 1984/8/31
Y1 - 1984/8/31
N2 - The depolarization of brain slices by high K+ concentrations in the presence of Ca2+ ions leads to the release from nerve terminals of endogenous excitatory neurotransmitters that interact with subsynaptic receptors controlling the neuronal membrane permeability to Na+ ions. This interaction has been studied by following the K+-evoked Ca2+-dependent 22Na+ efflux from 22Na+-preloaded slices from the cortex, striatum, hippocampus, cerebellum, substantia nigra and hypothalamus of the rat. The results indicate that the so-called N-methyl-d-aspartate receptor mediates the bulk of the excitatory transactions in the cortex and striatum whereas a subsynaptic glutamate receptor may mediate those in the hippocampus and cerebellum.
AB - The depolarization of brain slices by high K+ concentrations in the presence of Ca2+ ions leads to the release from nerve terminals of endogenous excitatory neurotransmitters that interact with subsynaptic receptors controlling the neuronal membrane permeability to Na+ ions. This interaction has been studied by following the K+-evoked Ca2+-dependent 22Na+ efflux from 22Na+-preloaded slices from the cortex, striatum, hippocampus, cerebellum, substantia nigra and hypothalamus of the rat. The results indicate that the so-called N-methyl-d-aspartate receptor mediates the bulk of the excitatory transactions in the cortex and striatum whereas a subsynaptic glutamate receptor may mediate those in the hippocampus and cerebellum.
KW - brain
KW - distribution
KW - excitatory amino acids
KW - rat
KW - subsynaptic receptors
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U2 - 10.1016/0304-3940(84)90310-0
DO - 10.1016/0304-3940(84)90310-0
M3 - Article
C2 - 6149499
AN - SCOPUS:0021132115
VL - 49
SP - 325
EP - 330
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -