Differential transplacental binding of valproic acid: influence of free fatty acids.

F. Albani, R. Riva, M. Contin, A. Baruzzi, M. Altomare, GP Merlini, E. Perucca

Research output: Contribution to journalArticlepeer-review

Abstract

The unbound fraction of valproic acid (VPA) was found to be significantly lower in cord serum (6.0 +/‐ 0.8%) than in maternal serum collected before oxytocin (12.2 +/‐ 2.7%) or after delivery (9.9 +/‐ 2.3%). The difference was probably due to the concentration of free fatty acids (acting as displacing agents) being higher in maternal serum. The transplacental binding gradient explains the clinical observation that total VPA levels at delivery are higher in the newborn than in the mother. 1984 The British Pharmacological Society

Original languageEnglish
Pages (from-to)759-762
Number of pages4
JournalBritish Journal of Clinical Pharmacology
Volume17
Issue number6
DOIs
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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