The replication cycles of a strain of human cytomegalovirus (CMV) and 2 strains of herpes simplex virus (HSV) were compared by electron microscopy. Either on the same or on different host cell systems 4 differential aspects were observed constantly. The presence in CMV infected cells of a large nuclear inclusion, lacking in HSV infected cells. The development of CMV capsids by microvesicular systems near the nuclear membrane, whereas HSV (types 1 and 2) uses the envelope from the inner lamina of the nuclear membrane. The presence in the cytoplasm of CMV infected cells of homogeneous dense material and dense microbodies, lacking in HSV infected cells; and the fact that in extracellular spaces homogeneous dense microbodies are present in CMV infected cell cultures only. The diagnostic usefulness of these differences are discussed.
|Translated title of the contribution||Differential ultrastructural elements of human cytomegalovirus and herpes simplex virus replication in human cell cultures|
|Number of pages||15|
|Journal||Giornale di Batteriologia Virologia ed Immunologia|
|Publication status||Published - 1975|
ASJC Scopus subject areas
- Immunology and Microbiology(all)