Differential up-regulation of D-1 and D-2 dopamine receptor function in mesostriatal areas but not in cortical-limbic brain regions of rats chronically treated with (-)sulpiride and SCH 23390

M. Memo, M. Pizzi, E. Nisoli, C. Missale, M. O. Carruba, P. Spano

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Abstract

In the present study, the possible functional modifications of both D-1 and D-2 dopamine (DA) receptor subtypes have been studied following chronic treatment with DA antagonists that selectively act on a single class of DA receptors. Particularly, the functional state of D-1 and D-2 receptors has been evaluated by measuring SKF 82526-stimulated and bromocriptine-inhibited adenylate cyclase activity in different brain regions of rats treated with saline, SCH 23390, or (-)sulpiride for 35 days. The results indicate that in striatum, nucleus accumbens, and substantia nigra, chronic blockade of D-1 DA receptors by SCH 23390 induces up-regulation of D-1 receptors without changing the functional activity of D-2 receptors. Likewise, chronic blockade of D-2 DA receptors by (-)sulpiride causes an up-regulation of D-2 but not D-1 DA receptors in striatum, nucleus accumbens, and substantia nigra. SCH 23390 or (-)sulpiride did not modify the functional activity of either D-1 or D-2 DA receptors located in frontal cortex and hippocampus. In conclusion, these results indicate that treatment with selective D-1 or D-2 DA receptor blockade for 5 weeks induces a receptor-specific up-regulation which involves the DA receptors located in the nigrostriatal system but not those present in the limbic-cortical areas.

Original languageEnglish
Pages (from-to)243-249
Number of pages7
JournalDrug Development Research
Volume11
Issue number3-4
Publication statusPublished - 1987

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Sulpiride
Dopamine Receptors
Rats
Brain
Up-Regulation
Nucleus Accumbens
Substantia Nigra
Fenoldopam
Bromocriptine
Dopamine Antagonists
SCH 23390
Frontal Lobe
Adenylyl Cyclases
Hippocampus

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

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Differential up-regulation of D-1 and D-2 dopamine receptor function in mesostriatal areas but not in cortical-limbic brain regions of rats chronically treated with (-)sulpiride and SCH 23390. / Memo, M.; Pizzi, M.; Nisoli, E.; Missale, C.; Carruba, M. O.; Spano, P.

In: Drug Development Research, Vol. 11, No. 3-4, 1987, p. 243-249.

Research output: Contribution to journalArticle

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AU - Spano, P.

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