Differentiating brain radionecrosis from tumour recurrence: a role for contrast-enhanced ultrasound?

Luca Mattei, Francesco Prada, Marcello Marchetti, Paola Gaviani, Francesco DiMeco

Research output: Contribution to journalArticlepeer-review


Differentiating radionecrosis from tumour recurrence is a major issue in neuro-oncology. Conventional imaging is far from being validated as an alternative to histological assessment. We report the case of a patient operated on for suspected recurrence of brain metastasis 9 months after cyberknife radiosurgery. While magnetic resonance imaging showed strong enhancement of the lesion, intraoperative contrast-enhanced ultrasonography (CEUS) surprisingly did not—different from what is expected for brain metastases. Histopathological examination documented radionecrosis. For the first time, we describe radionecrosis with CEUS; further investigation is needed; however, the lack of enhancement could represent an important hallmark in differential diagnosis with neoplastic tissue.

Original languageEnglish
Pages (from-to)2405-2408
Number of pages4
JournalActa Neurochirurgica
Issue number12
Publication statusPublished - Dec 1 2017
Externally publishedYes


  • Brain radionecrosis
  • Contrast
  • Metastasis
  • Ultrasound

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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