Differentiation between recurrent tumor and benign conditions after treatment of gynecologic pelvic carcinoma: Value of dynamic contrast-enhanced subtraction MR imaging

Karen Kinkel, Michèle Ariche, Anne A. Tardivon, Alain Spatz, Damienne Castaigne, Catherine Lhommé, Daniel Vanel

Research output: Contribution to journalArticle

Abstract

PURPOSE: To compare dynamic contrast material-enhanced subtraction and T2-weighted spin-echo (SE) magnetic resonance (MR) imaging in the differentiation of fibrosis from tumor recurrence during the follow-up of treated gynecologic pelvic malignancy. MATERIALS AND METHODS: Thirty-four patients (aged 24-82 years) with 18 benign and 35 malignant lesions confirmed by means of surgery (n = 18), biopsy (n = 25), or 18-month follow-up examination (n = 10) underwent dynamic contrast-enhanced subtraction and T2- weighted SE MR imaging. Contrast material enhancement of an abnormal pelvic structure within the first 90 seconds on dynamic contrast-enhanced subtraction images or high signal intensity on T2-weighted SE images was considered indicative of malignancy. RESULTS: The sensitivity, specificity, accuracy, and positive and negative predictive values were 91%, 67%, 83%, 86%, and 86%, respectively, for dynamic contrast-enhanced subtraction imaging and 91%, 22%, 68%, 70%, and 57%, respectively, for T2-weighted SE imaging. More lesions were correctly classified with dynamic contrast-enhanced subtraction imaging than with T2-weighted SE imaging (P <.01). CONCLUSION: Dynamic contrast-enhanced subtraction imaging is more accurate than T2- weighted SE imaging for differentiating fibrosis from tumor recurrence during the follow-up of treated gynecologic pelvic malignancy. However, use of both sequences is recommended.

Original languageEnglish
Pages (from-to)55-63
Number of pages9
JournalRadiology
Volume204
Issue number1
Publication statusPublished - Jul 1997

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Magnetic Resonance Imaging
Carcinoma
Neoplasms
Contrast Media
Fibrosis
Therapeutics
Recurrence
Biopsy
Sensitivity and Specificity

Keywords

  • Magnetic resonance (MR), contrast enhancement
  • Magnetic resonance (MR), technology
  • Ovary, neoplasms
  • Pelvic organs, neoplasms
  • Uterine neoplasms

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Kinkel, K., Ariche, M., Tardivon, A. A., Spatz, A., Castaigne, D., Lhommé, C., & Vanel, D. (1997). Differentiation between recurrent tumor and benign conditions after treatment of gynecologic pelvic carcinoma: Value of dynamic contrast-enhanced subtraction MR imaging. Radiology, 204(1), 55-63.

Differentiation between recurrent tumor and benign conditions after treatment of gynecologic pelvic carcinoma : Value of dynamic contrast-enhanced subtraction MR imaging. / Kinkel, Karen; Ariche, Michèle; Tardivon, Anne A.; Spatz, Alain; Castaigne, Damienne; Lhommé, Catherine; Vanel, Daniel.

In: Radiology, Vol. 204, No. 1, 07.1997, p. 55-63.

Research output: Contribution to journalArticle

Kinkel, K, Ariche, M, Tardivon, AA, Spatz, A, Castaigne, D, Lhommé, C & Vanel, D 1997, 'Differentiation between recurrent tumor and benign conditions after treatment of gynecologic pelvic carcinoma: Value of dynamic contrast-enhanced subtraction MR imaging', Radiology, vol. 204, no. 1, pp. 55-63.
Kinkel, Karen ; Ariche, Michèle ; Tardivon, Anne A. ; Spatz, Alain ; Castaigne, Damienne ; Lhommé, Catherine ; Vanel, Daniel. / Differentiation between recurrent tumor and benign conditions after treatment of gynecologic pelvic carcinoma : Value of dynamic contrast-enhanced subtraction MR imaging. In: Radiology. 1997 ; Vol. 204, No. 1. pp. 55-63.
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