Differentiation, expansion, and homeostasis of autoreactive T cells in type 1 diabetes mellitus

Paolo Monti, Anne Kristin Heninger, Ezio Bonifacio

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Autoreactive T cells play a major role in the pathogenesis of type 1 diabetes mellitus (T1DM) and are considered a major target of immunomodulatory strategies aimed at preventing or delaying the disease onset. However, the T-cell response against insulinproducing β cells is still poorly understood. T cells potentially able to recognize and destroy β cells are present in most individuals, but only in a few do they differentiate into pathogenic effectors. Recent and novel findings in T-cell biology on the dynamics of T-cell activation and memory maintenance are shedding new light on the general mechanisms of the T-cell response. In this article, we discuss how new discoveries about T-cell differentiation, expansion, and homeostasis could help to clarify mechanisms of autoimmunity that lead to T1DM.

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalCurrent Diabetes Reports
Volume9
Issue number2
DOIs
Publication statusPublished - 2009

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Type 1 Diabetes Mellitus
Homeostasis
T-Lymphocytes
Autoimmunity
Cell Biology
Cell Differentiation
Maintenance

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Differentiation, expansion, and homeostasis of autoreactive T cells in type 1 diabetes mellitus. / Monti, Paolo; Heninger, Anne Kristin; Bonifacio, Ezio.

In: Current Diabetes Reports, Vol. 9, No. 2, 2009, p. 113-118.

Research output: Contribution to journalArticle

Monti, Paolo ; Heninger, Anne Kristin ; Bonifacio, Ezio. / Differentiation, expansion, and homeostasis of autoreactive T cells in type 1 diabetes mellitus. In: Current Diabetes Reports. 2009 ; Vol. 9, No. 2. pp. 113-118.
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