Differentiation of clinically non-functioning pituitary adenomas from meningiomas and craniopharyngiomas by positron emission tomography with [18F]fluoro-ethyl-spiperone

Giovanni Lucignani, Marco Losa, Rosa Maria Moresco, Angelo Del Sole, Mario Matarrese, Valentino Bettinardi, Pietro Mortini, Massimo Giovanelli, Ferruccio Fazio

Research output: Contribution to journalArticle

Abstract

The differential diagnosis among various types of non-functioning sellar and parasellar rumours is sometimes difficult using currently available methods of morphological imaging. The aim of this study was to define whether assessment of the uptake of [18F]fluoro-ethyl-spiperone (FESP) with positron emission tomography (PET) could be helpful for the differential diagnosis of pituitary adenomas and other parasellar lesions, and for establishing the appropriate therapeutic approach. The population examined comprised 16 patients with the diagnosis of primary tumour of the sellar/parasellar region who were waiting to undergo surgical treatment. The results demonstrated that PET with [18F]FESP is a very specific method for differentiating adenomas from craniopharyngiomas and meningiomas. The visual interpretation of images allows such differentiation at approximately 70 min after tracer injection. Semiquantitative analysis of the dynamic PET data confirmed the results of visual interpretation, demonstrating that the uptake of [18F]FESP was consistently (i.e. throughout the series) at least two- to threefold higher in non-functioning adenomas than in other parasellar tumours as early as 70 min after tracer injection, and that it increased still further thereafter. It is concluded that PET with [18F]FESP might be of clinical value in those cases in which the differential diagnosis among various histological types of sellar tumour is uncertain with conventional methods.

Original languageEnglish
Pages (from-to)1149-1155
Number of pages7
JournalEuropean Journal Of Nuclear Medicine
Volume24
Issue number9
DOIs
Publication statusPublished - 1997

Keywords

  • Dopaminergic
  • Neoplasm
  • Pituitary
  • Receptor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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