TY - JOUR
T1 - Differentiation pathways in primary invasive breast carcinoma as suggested by intermediate filament and biopathological marker expression
AU - Santini, Donatella
AU - Ceccarelli, Claudio
AU - Taffurelli, Mario
AU - Pileri, Stefano
AU - Marrano, Domenico
PY - 1996
Y1 - 1996
N2 - The expression of intermediate filament proteins (IFPs) in 65 primary breast carcinomas was analysed by a panel of specific antibodies. Results were integrated with the oestrogen and progesterone receptor (ER and PGR) status, Ki-67 marking, and epidermal growth factor receptor (EGFr) expression. Invasive breast carcinomas could be divided into three main groups: group 1 revealed positivity only for 'simple epithelial' cytokeratins (CKs 7, 8, 18, and 19); group 2 also stained with the antibodies K8.12 and 34βE12; while group 3 shelved co-expression of CKs 14 and 17, vimentin, and α-smooth muscle actin. Group 3 consistently comprised tumours with the highest Ki-67 levels, EGFr positivity, and ER-PGR negative status. On the other hand, groups 1 and 2 usually exhibited a positive hormonal status, lower proliferative activity, and EGFr negativity. The results of this study indicate that the determination of IFPs can significantly contribute to the identification of groups of patients with different biopathological settings and possibly different clinical behaviour.
AB - The expression of intermediate filament proteins (IFPs) in 65 primary breast carcinomas was analysed by a panel of specific antibodies. Results were integrated with the oestrogen and progesterone receptor (ER and PGR) status, Ki-67 marking, and epidermal growth factor receptor (EGFr) expression. Invasive breast carcinomas could be divided into three main groups: group 1 revealed positivity only for 'simple epithelial' cytokeratins (CKs 7, 8, 18, and 19); group 2 also stained with the antibodies K8.12 and 34βE12; while group 3 shelved co-expression of CKs 14 and 17, vimentin, and α-smooth muscle actin. Group 3 consistently comprised tumours with the highest Ki-67 levels, EGFr positivity, and ER-PGR negative status. On the other hand, groups 1 and 2 usually exhibited a positive hormonal status, lower proliferative activity, and EGFr negativity. The results of this study indicate that the determination of IFPs can significantly contribute to the identification of groups of patients with different biopathological settings and possibly different clinical behaviour.
KW - Breast cancer
KW - Epidermal growth factor rceptor
KW - Immunohistochemistry
KW - Intermediate filaments
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U2 - 10.1002/(SICI)1096-9896(199608)179:4<386::AID-PATH631>3.0.CO;2-V
DO - 10.1002/(SICI)1096-9896(199608)179:4<386::AID-PATH631>3.0.CO;2-V
M3 - Article
C2 - 8869285
AN - SCOPUS:0029793758
VL - 179
SP - 386
EP - 391
JO - Journal of Pathology
JF - Journal of Pathology
SN - 0022-3417
IS - 4
ER -