Differentiation pathways in primary invasive breast carcinoma as suggested by intermediate filament and biopathological marker expression

Donatella Santini, Claudio Ceccarelli, Mario Taffurelli, Stefano Pileri, Domenico Marrano

Research output: Contribution to journalArticlepeer-review

Abstract

The expression of intermediate filament proteins (IFPs) in 65 primary breast carcinomas was analysed by a panel of specific antibodies. Results were integrated with the oestrogen and progesterone receptor (ER and PGR) status, Ki-67 marking, and epidermal growth factor receptor (EGFr) expression. Invasive breast carcinomas could be divided into three main groups: group 1 revealed positivity only for 'simple epithelial' cytokeratins (CKs 7, 8, 18, and 19); group 2 also stained with the antibodies K8.12 and 34βE12; while group 3 shelved co-expression of CKs 14 and 17, vimentin, and α-smooth muscle actin. Group 3 consistently comprised tumours with the highest Ki-67 levels, EGFr positivity, and ER-PGR negative status. On the other hand, groups 1 and 2 usually exhibited a positive hormonal status, lower proliferative activity, and EGFr negativity. The results of this study indicate that the determination of IFPs can significantly contribute to the identification of groups of patients with different biopathological settings and possibly different clinical behaviour.

Original languageEnglish
Pages (from-to)386-391
Number of pages6
JournalJournal of Pathology
Volume179
Issue number4
DOIs
Publication statusPublished - 1996

Keywords

  • Breast cancer
  • Epidermal growth factor rceptor
  • Immunohistochemistry
  • Intermediate filaments

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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