Differing clinical features between Japanese and Caucasian patients with myelodysplastic syndromes: Analysis from the International Working Group for Prognosis of MDS

Yasushi Miyazaki, Heinz Tuechler, Guillermo Sanz, Julie Schanz, Guillermo Garcia-Manero, Francesc Solé, John M. Bennett, David Bowen, Pierre Fenaux, Francois Dreyfus, Hagop Kantarjian, Andrea Kuendgen, Luca Malcovati, Mario Cazzola, Jaroslav Cermak, Christa Fonatsch, Michelle M. Le Beau, Marilyn L. Slovak, Valeria Santini, Michael LübbertJaroslaw Maciejewski, Sigrid Machherndl-Spandl, Silvia M.M. Magalhaes, Michael Pfeilstöcker, Mikkael A. Sekeres, Wolfgang R. Sperr, Reinhard Stauder, Sudhir Tauro, Peter Valent, Teresa Vallespi, Arjan A. van de Loosdrecht, Ulrich Germing, Detlef Haase, Peter L. Greenberg

Research output: Contribution to journalArticle

Abstract

Clinical features of myelodysplastic syndromes (MDS) could be influenced by many factors, such as disease intrinsic factors (e.g., morphologic, cytogenetic, molecular), extrinsic factors (e.g, management, environment), and ethnicity. Several previous studies have suggested such differences between Asian and European/USA countries. In this study, to elucidate potential differences in primary untreated MDS between Japanese (JPN) and Caucasians (CAUC), we analyzed the data from a large international database collected by the International Working Group for Prognosis of MDS (300 and 5838 patients, respectively). JPN MDS were significantly younger with more severe cytopenias, and cytogenetic differences: less del(5q) and more +1/+1q, -1/del(1p), der(1;7), -9/del(9q), del(16q), and del(20q). Although differences in time to acute myeloid leukemia transformation did not occur, a significantly better survival in JPN was demonstrated, even after the adjustment for age and FAB subtypes, especially in lower, but not in higher prognostic risk categories. Certain clinical factors (cytopenias, blast percentage, cytogenetic risk) had different impact on survival and time to transformation to leukemia between the two groups. Although possible confounding events (e.g., environment, diet, and access to care) could not be excluded, our results indicated the existence of clinically relevant ethnic differences regarding survival in MDS between JPN and CAUC patients. The good performance of the IPSS-R in both CAUC and JP patients underlines that its common risk model is adequate for CAUC and JP.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalLeukemia Research
Volume73
DOIs
Publication statusPublished - Oct 1 2018

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Myelodysplastic Syndromes
Cytogenetics
Survival
Intrinsic Factor
Acute Myeloid Leukemia
Leukemia
Databases
Diet

Keywords

  • Clinical features
  • Ethnicity
  • Karyotype
  • Myelodysplastic syndromes
  • Survival

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Differing clinical features between Japanese and Caucasian patients with myelodysplastic syndromes : Analysis from the International Working Group for Prognosis of MDS. / Miyazaki, Yasushi; Tuechler, Heinz; Sanz, Guillermo; Schanz, Julie; Garcia-Manero, Guillermo; Solé, Francesc; Bennett, John M.; Bowen, David; Fenaux, Pierre; Dreyfus, Francois; Kantarjian, Hagop; Kuendgen, Andrea; Malcovati, Luca; Cazzola, Mario; Cermak, Jaroslav; Fonatsch, Christa; Le Beau, Michelle M.; Slovak, Marilyn L.; Santini, Valeria; Lübbert, Michael; Maciejewski, Jaroslaw; Machherndl-Spandl, Sigrid; Magalhaes, Silvia M.M.; Pfeilstöcker, Michael; Sekeres, Mikkael A.; Sperr, Wolfgang R.; Stauder, Reinhard; Tauro, Sudhir; Valent, Peter; Vallespi, Teresa; van de Loosdrecht, Arjan A.; Germing, Ulrich; Haase, Detlef; Greenberg, Peter L.

In: Leukemia Research, Vol. 73, 01.10.2018, p. 51-57.

Research output: Contribution to journalArticle

Miyazaki, Y, Tuechler, H, Sanz, G, Schanz, J, Garcia-Manero, G, Solé, F, Bennett, JM, Bowen, D, Fenaux, P, Dreyfus, F, Kantarjian, H, Kuendgen, A, Malcovati, L, Cazzola, M, Cermak, J, Fonatsch, C, Le Beau, MM, Slovak, ML, Santini, V, Lübbert, M, Maciejewski, J, Machherndl-Spandl, S, Magalhaes, SMM, Pfeilstöcker, M, Sekeres, MA, Sperr, WR, Stauder, R, Tauro, S, Valent, P, Vallespi, T, van de Loosdrecht, AA, Germing, U, Haase, D & Greenberg, PL 2018, 'Differing clinical features between Japanese and Caucasian patients with myelodysplastic syndromes: Analysis from the International Working Group for Prognosis of MDS', Leukemia Research, vol. 73, pp. 51-57. https://doi.org/10.1016/j.leukres.2018.08.022
Miyazaki, Yasushi ; Tuechler, Heinz ; Sanz, Guillermo ; Schanz, Julie ; Garcia-Manero, Guillermo ; Solé, Francesc ; Bennett, John M. ; Bowen, David ; Fenaux, Pierre ; Dreyfus, Francois ; Kantarjian, Hagop ; Kuendgen, Andrea ; Malcovati, Luca ; Cazzola, Mario ; Cermak, Jaroslav ; Fonatsch, Christa ; Le Beau, Michelle M. ; Slovak, Marilyn L. ; Santini, Valeria ; Lübbert, Michael ; Maciejewski, Jaroslaw ; Machherndl-Spandl, Sigrid ; Magalhaes, Silvia M.M. ; Pfeilstöcker, Michael ; Sekeres, Mikkael A. ; Sperr, Wolfgang R. ; Stauder, Reinhard ; Tauro, Sudhir ; Valent, Peter ; Vallespi, Teresa ; van de Loosdrecht, Arjan A. ; Germing, Ulrich ; Haase, Detlef ; Greenberg, Peter L. / Differing clinical features between Japanese and Caucasian patients with myelodysplastic syndromes : Analysis from the International Working Group for Prognosis of MDS. In: Leukemia Research. 2018 ; Vol. 73. pp. 51-57.
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abstract = "Clinical features of myelodysplastic syndromes (MDS) could be influenced by many factors, such as disease intrinsic factors (e.g., morphologic, cytogenetic, molecular), extrinsic factors (e.g, management, environment), and ethnicity. Several previous studies have suggested such differences between Asian and European/USA countries. In this study, to elucidate potential differences in primary untreated MDS between Japanese (JPN) and Caucasians (CAUC), we analyzed the data from a large international database collected by the International Working Group for Prognosis of MDS (300 and 5838 patients, respectively). JPN MDS were significantly younger with more severe cytopenias, and cytogenetic differences: less del(5q) and more +1/+1q, -1/del(1p), der(1;7), -9/del(9q), del(16q), and del(20q). Although differences in time to acute myeloid leukemia transformation did not occur, a significantly better survival in JPN was demonstrated, even after the adjustment for age and FAB subtypes, especially in lower, but not in higher prognostic risk categories. Certain clinical factors (cytopenias, blast percentage, cytogenetic risk) had different impact on survival and time to transformation to leukemia between the two groups. Although possible confounding events (e.g., environment, diet, and access to care) could not be excluded, our results indicated the existence of clinically relevant ethnic differences regarding survival in MDS between JPN and CAUC patients. The good performance of the IPSS-R in both CAUC and JP patients underlines that its common risk model is adequate for CAUC and JP.",
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T2 - Analysis from the International Working Group for Prognosis of MDS

AU - Miyazaki, Yasushi

AU - Tuechler, Heinz

AU - Sanz, Guillermo

AU - Schanz, Julie

AU - Garcia-Manero, Guillermo

AU - Solé, Francesc

AU - Bennett, John M.

AU - Bowen, David

AU - Fenaux, Pierre

AU - Dreyfus, Francois

AU - Kantarjian, Hagop

AU - Kuendgen, Andrea

AU - Malcovati, Luca

AU - Cazzola, Mario

AU - Cermak, Jaroslav

AU - Fonatsch, Christa

AU - Le Beau, Michelle M.

AU - Slovak, Marilyn L.

AU - Santini, Valeria

AU - Lübbert, Michael

AU - Maciejewski, Jaroslaw

AU - Machherndl-Spandl, Sigrid

AU - Magalhaes, Silvia M.M.

AU - Pfeilstöcker, Michael

AU - Sekeres, Mikkael A.

AU - Sperr, Wolfgang R.

AU - Stauder, Reinhard

AU - Tauro, Sudhir

AU - Valent, Peter

AU - Vallespi, Teresa

AU - van de Loosdrecht, Arjan A.

AU - Germing, Ulrich

AU - Haase, Detlef

AU - Greenberg, Peter L.

PY - 2018/10/1

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N2 - Clinical features of myelodysplastic syndromes (MDS) could be influenced by many factors, such as disease intrinsic factors (e.g., morphologic, cytogenetic, molecular), extrinsic factors (e.g, management, environment), and ethnicity. Several previous studies have suggested such differences between Asian and European/USA countries. In this study, to elucidate potential differences in primary untreated MDS between Japanese (JPN) and Caucasians (CAUC), we analyzed the data from a large international database collected by the International Working Group for Prognosis of MDS (300 and 5838 patients, respectively). JPN MDS were significantly younger with more severe cytopenias, and cytogenetic differences: less del(5q) and more +1/+1q, -1/del(1p), der(1;7), -9/del(9q), del(16q), and del(20q). Although differences in time to acute myeloid leukemia transformation did not occur, a significantly better survival in JPN was demonstrated, even after the adjustment for age and FAB subtypes, especially in lower, but not in higher prognostic risk categories. Certain clinical factors (cytopenias, blast percentage, cytogenetic risk) had different impact on survival and time to transformation to leukemia between the two groups. Although possible confounding events (e.g., environment, diet, and access to care) could not be excluded, our results indicated the existence of clinically relevant ethnic differences regarding survival in MDS between JPN and CAUC patients. The good performance of the IPSS-R in both CAUC and JP patients underlines that its common risk model is adequate for CAUC and JP.

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