Difficult to control atopic dermatitis

Ulf Darsow, Andreas Wollenberg, Dagmar Simon, Alain Taïeb, Thomas Werfel, Arnold Oranje, Carlo Gelmetti, Ake Svensson, Mette Deleuran, Anne Marie Calza, Francesca Giusti, Jann Lübbe, Stefania Seidenari, Johannes Ring

Research output: Contribution to journalArticle


Difficult to control atopic dermatitis (AD) presents a therapeutic challenge and often requires combinations of topical and systemic treatment. Anti-inflammatory treatment of severe AD most commonly includes topical glucocorticosteroids and topical calcineurin antagonists used for exacerbation management and more recently for proactive therapy in selected cases. Topical corticosteroids remain the mainstay of therapy, the topical calcineurin inhibitors tacrolimus and pimecrolimus are preferred in certain locations. Systemic anti-inflammatory treatment is an option for severe refractory cases. Microbial colonization and superinfection contribute to disease exacerbation and thus justify additional antimicrobial/antiseptic treatment. Systemic antihistamines (H1) may relieve pruritus but do not have sufficient effect on eczema. Adjuvant therapy includes UV irradiation preferably of UVA1 wavelength. "Eczema school" educational programs have been proven to be helpful.

Original languageEnglish
Article number6
JournalWorld Allergy Organization Journal
Issue number1
Publication statusPublished - 2013



  • Atopic dermatitis
  • Eczema
  • Guideline
  • Therapy

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Darsow, U., Wollenberg, A., Simon, D., Taïeb, A., Werfel, T., Oranje, A., Gelmetti, C., Svensson, A., Deleuran, M., Calza, A. M., Giusti, F., Lübbe, J., Seidenari, S., & Ring, J. (2013). Difficult to control atopic dermatitis. World Allergy Organization Journal, 6(1), [6]. https://doi.org/10.1186/1939-4551-6-6