Diffuse Brain Hypoperfusion in Advanced Leukoencephalopathy with Calcifications and Cysts

Emanuele Bartolini, Andrea Bianchi, Ilaria Bartolomei, Alessandra Vella, Lapo Sali, Antonio Ciccarone, Fabrizio Salvi, Mario Mascalchi

Research output: Contribution to journalArticle


Leukoencephalopathy with calcifications and cysts (LCC) is an uncommon condition of unknown etiology occurring in children and adults. Pathological findings include obliterative hyalinosis of the small vessels, myelin loss, intense gliosis, Rosenthal fiber formation, microcalcifications, and hemosiderin deposits. Herein we report a 55-year-old man with LCC documented 10 years ago, in whom we examined brain perfusion by pseudocontinuous arterial spin labeling technique. We demonstrated diffused hypoperfusion of the affected white matter (WM) and of the subcortical gray matter (GM) and cortical GM in the patient in comparison to a group of healthy control subjects, using both qualitative evaluation and region of interest analysis. WM and subcortical GM hypoperfusion reflects the known distribution of LCC microangiopathy. We speculate that cortical hypoperfusion may be related to cerebral atrophy or may reflect deafferentation secondary to severe leukoencephalopathy, and may possibly contribute to severe motor and cognitive impairment. Further studies addressing cerebral blood flow in LCC are necessary.

Original languageEnglish
Pages (from-to)e111-e113
JournalJournal of Stroke and Cerebrovascular Diseases
Issue number8
Publication statusPublished - 2016


  • 3-T MRI
  • Arterial spin labeling
  • Neuroimaging
  • Perfusion
  • Perfusion MRI
  • Regional CBF
  • White matter

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Rehabilitation
  • Cardiology and Cardiovascular Medicine

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