Diffuse Brain Hypoperfusion in Advanced Leukoencephalopathy with Calcifications and Cysts

Emanuele Bartolini, Andrea Bianchi, Ilaria Bartolomei, Alessandra Vella, Lapo Sali, Antonio Ciccarone, Fabrizio Salvi, Mario Mascalchi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Leukoencephalopathy with calcifications and cysts (LCC) is an uncommon condition of unknown etiology occurring in children and adults. Pathological findings include obliterative hyalinosis of the small vessels, myelin loss, intense gliosis, Rosenthal fiber formation, microcalcifications, and hemosiderin deposits. Herein we report a 55-year-old man with LCC documented 10 years ago, in whom we examined brain perfusion by pseudocontinuous arterial spin labeling technique. We demonstrated diffused hypoperfusion of the affected white matter (WM) and of the subcortical gray matter (GM) and cortical GM in the patient in comparison to a group of healthy control subjects, using both qualitative evaluation and region of interest analysis. WM and subcortical GM hypoperfusion reflects the known distribution of LCC microangiopathy. We speculate that cortical hypoperfusion may be related to cerebral atrophy or may reflect deafferentation secondary to severe leukoencephalopathy, and may possibly contribute to severe motor and cognitive impairment. Further studies addressing cerebral blood flow in LCC are necessary.

Original languageEnglish
Pages (from-to)e111-e113
JournalJournal of Stroke and Cerebrovascular Diseases
Volume25
Issue number8
DOIs
Publication statusPublished - 2016

Fingerprint

Leukoencephalopathies
Cysts
Brain
Cerebrovascular Circulation
Hemosiderin
Calcinosis
Gliosis
Myelin Sheath
Atrophy
Healthy Volunteers
Perfusion
Control Groups
Gray Matter

Keywords

  • 3-T MRI
  • Arterial spin labeling
  • Neuroimaging
  • Perfusion
  • Perfusion MRI
  • Regional CBF
  • White matter

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Rehabilitation
  • Cardiology and Cardiovascular Medicine

Cite this

Diffuse Brain Hypoperfusion in Advanced Leukoencephalopathy with Calcifications and Cysts. / Bartolini, Emanuele; Bianchi, Andrea; Bartolomei, Ilaria; Vella, Alessandra; Sali, Lapo; Ciccarone, Antonio; Salvi, Fabrizio; Mascalchi, Mario.

In: Journal of Stroke and Cerebrovascular Diseases, Vol. 25, No. 8, 2016, p. e111-e113.

Research output: Contribution to journalArticle

Bartolini, Emanuele ; Bianchi, Andrea ; Bartolomei, Ilaria ; Vella, Alessandra ; Sali, Lapo ; Ciccarone, Antonio ; Salvi, Fabrizio ; Mascalchi, Mario. / Diffuse Brain Hypoperfusion in Advanced Leukoencephalopathy with Calcifications and Cysts. In: Journal of Stroke and Cerebrovascular Diseases. 2016 ; Vol. 25, No. 8. pp. e111-e113.
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