TY - JOUR
T1 - Diffuse febrile dermatosis in a patient with active ulcerative colitis under treatment with steroids and azathioprine
T2 - A case of Sweet's syndrome - Case report and review of literature
AU - Paoluzi, O. A.
AU - Crispino, P.
AU - Amantea, A.
AU - Pica, R.
AU - Iacopini, F.
AU - Consolazio, A.
AU - Di Palma, V.
AU - Rivera, M.
AU - Paoluzi, P.
PY - 2004/5
Y1 - 2004/5
N2 - Ulcerative colitis is an inflammatory bowel disease often associated with extra-intestinal manifestations, such as dermatological disorders. Of these, the most frequent are erythema nodosum and pyoderma gangrenosum, the two neutrophilic forms of dermatosis. Another is Sweet's syndrome, which results in a sudden eruption of tender, raised erythematous or violaceous plaques/papules or nodules, less frequent vesicles, pustules or bullae, involving face, neck, arms and trunk. This skin disorder is frequently observed in patients with leukaemia or connective tissue diseases, while it is very rare in patients with inflammatory bowel disease. The present report deals with the case of a febrile diffuse skin eruption in a 53-year-old patient with moderately active ulcerative colitis after few days' treatment with steroids and azathioprine. At first, the dermatosis was addressed to an idiosyncrasy to azathioprine, which was, therefore, promptly discontinued. Histological examination of skin biopsies revealed the presence of features typical of a Sweet's syndrome. The eruption gradually improved as well as the patient's general condition, until complete regression was achieved following steroid treatment.
AB - Ulcerative colitis is an inflammatory bowel disease often associated with extra-intestinal manifestations, such as dermatological disorders. Of these, the most frequent are erythema nodosum and pyoderma gangrenosum, the two neutrophilic forms of dermatosis. Another is Sweet's syndrome, which results in a sudden eruption of tender, raised erythematous or violaceous plaques/papules or nodules, less frequent vesicles, pustules or bullae, involving face, neck, arms and trunk. This skin disorder is frequently observed in patients with leukaemia or connective tissue diseases, while it is very rare in patients with inflammatory bowel disease. The present report deals with the case of a febrile diffuse skin eruption in a 53-year-old patient with moderately active ulcerative colitis after few days' treatment with steroids and azathioprine. At first, the dermatosis was addressed to an idiosyncrasy to azathioprine, which was, therefore, promptly discontinued. Histological examination of skin biopsies revealed the presence of features typical of a Sweet's syndrome. The eruption gradually improved as well as the patient's general condition, until complete regression was achieved following steroid treatment.
KW - Azathioprine
KW - Inflammatory bowel disease
KW - Neutrophilic dermatosis
KW - Sweet's syndrome
KW - Ulcerative colitis
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UR - http://www.scopus.com/inward/citedby.url?scp=4544352000&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2003.10.020
DO - 10.1016/j.dld.2003.10.020
M3 - Review article
C2 - 15191207
AN - SCOPUS:4544352000
VL - 36
SP - 361
EP - 366
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 5
ER -