Diffuse metabolic changes in the brain of patients with familial amyloid polyneuropathy. A proton MRSI study

Anna Mazzeo, Antonio Toscano, Maria L. Stromillo, Marco Battaglini, Corrado Messina, Antonio Federico, Giuseppe Vita, Nicola De Stefano

Research output: Contribution to journalArticle

Abstract

Objectives: To assess brain metabolic abnormalities in patients with familial amyloid polyneuropathy (FAP) due to the transthyretin (TTR) gene mutations. Background: The TTR-FAP has variable phenotypic expression, which includes abnormalities of the central nervous system (CNS). Several conventional MRI studies have shown brain abnormalities, probably secondary to amyloid accumulation in leptomeningeal and subarachnoid vessels. However, TTR-related amyloid deposits do not seem to significantly affect the brain parenchyma and a prominent CNS impairment is considered to be rare in TTR amyloidosis. Methods: We performed proton MR spectroscopic imaging (1H-MRSI) in the central brain of four unrelated TTR-FAP patients with either minimal or no signs of neurological involvement and eight age- and sex-matched normal controls (NC). Metabolic changes were assessed in the entire volume of interest (VOI) and in the frontal, periventricular and posterior white matter (WM). Results: Conventional MRI was normal in 2 patients and showed minimal WM lesions in the remaining 2 patients. 1H-MRSI showed N-acetylaspartate to creatine ratio (NAA/Cr) decreases in the central brain VOI in all TTR-FAP patients (p <0.005). These NAA/Cr decreases were homogeneous in all WM regions (p <0.05 for all). Conclusions: 1H-MRSI findings suggest that diffuse metabolic changes, probably related to axonal damage, are present in brains of TTR-FAP patients even when they have no or minimal clinical and MRI signs of CNS involvement. The mechanism leading to sub-clinical metabolic brain changes needs to be identified.

Original languageEnglish
Pages (from-to)31-35
Number of pages5
JournalJournal of the Neurological Sciences
Volume246
Issue number1-2
DOIs
Publication statusPublished - Jul 15 2006

Keywords

  • Axonal damage
  • Brain
  • Familial amyloid polyneuropathy
  • Magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

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    Mazzeo, A., Toscano, A., Stromillo, M. L., Battaglini, M., Messina, C., Federico, A., Vita, G., & De Stefano, N. (2006). Diffuse metabolic changes in the brain of patients with familial amyloid polyneuropathy. A proton MRSI study. Journal of the Neurological Sciences, 246(1-2), 31-35. https://doi.org/10.1016/j.jns.2006.01.017