Diffuse thalamic degeneration in fatal familial insomnia. A morphometric study

Giorgio MacChi, Giacomina Rossi, Anna Laura Abbamondi, Giorgio Giaccone, Domenico Mancia, Fabrizio Tagliavini, Orso Bugiani

Research output: Contribution to journalArticlepeer-review

Abstract

A morphometric investigation disclosed most thalamic nuclei severely degenerated in two patients with fatal familial insomnia. Associative and motor nuclei lost 90% neurons, and limbic-paralimbic, intralaminar and reticular nuclei lost 60%. These findings point to the disorganization of most thalamic circuits as a condition necessary for the sleep-wake rhythm being affected.

Original languageEnglish
Pages (from-to)154-158
Number of pages5
JournalBrain Research
Volume771
Issue number1
DOIs
Publication statusPublished - Oct 10 1997

Keywords

  • Insomnia
  • Prion disease
  • Thalamus

ASJC Scopus subject areas

  • Neuroscience(all)

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