Diffusion anisotropy of the cervical cord is strictly associated with disability in amyotrophic lateral sclerosis

P. Valsasina, F. Agosta, B. Benedetti, D. Caputo, M. Perini, F. Salvi, A. Prelle, M. Filippi

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with severe cervical cord damage due to degeneration of the corticospinal tracts and loss of lower motor neurones. Diffusion tensor magnetic resonance imaging (DT MRI) allows the measurement of quantities reflecting the size (such as mean diffusivity) and orientation (such as fractional anisotropy) of water-filled spaces in biological tissues. Methods: Mean diffusivity and fractional anisotropy histograms from the cervical cord of patients with ALS were obtained to: (1) quantify the extent of tissue damage in this critical central nervous system region; and (2) investigate the magnitude of the correlation of cervical cord DT MRI metrics with patients' disability and tissue damage along the brain portion of the corticospinal tracts. Cervical cord and brain DT MRI scans were obtained from 28 patients with ALS and 20 age-matched and sex-matched controls. Cord mean diffusivity and fractional anisotropy histograms were produced and the cord cross-sectional area was measured. Average mean diffusivity and fractional anisotropy along the brain portion of the corticospinal tracts were also measured. Results: Compared with controls, patients with ALS had significantly lower mean fractional anisotropy (p = 0.002) and cord cross-sectional area (p

Original languageEnglish
Pages (from-to)480-484
Number of pages5
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume78
Issue number5
DOIs
Publication statusPublished - May 2007

Fingerprint

Anisotropy
Amyotrophic Lateral Sclerosis
Pyramidal Tracts
Diffusion Magnetic Resonance Imaging
Brain
Motor Neurons
Neurodegenerative Diseases
Central Nervous System
Cervical Cord
Water

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health
  • Medicine(all)

Cite this

Diffusion anisotropy of the cervical cord is strictly associated with disability in amyotrophic lateral sclerosis. / Valsasina, P.; Agosta, F.; Benedetti, B.; Caputo, D.; Perini, M.; Salvi, F.; Prelle, A.; Filippi, M.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 78, No. 5, 05.2007, p. 480-484.

Research output: Contribution to journalArticle

@article{5ed5a29890794fe79a54a68680b97cfa,
title = "Diffusion anisotropy of the cervical cord is strictly associated with disability in amyotrophic lateral sclerosis",
abstract = "Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with severe cervical cord damage due to degeneration of the corticospinal tracts and loss of lower motor neurones. Diffusion tensor magnetic resonance imaging (DT MRI) allows the measurement of quantities reflecting the size (such as mean diffusivity) and orientation (such as fractional anisotropy) of water-filled spaces in biological tissues. Methods: Mean diffusivity and fractional anisotropy histograms from the cervical cord of patients with ALS were obtained to: (1) quantify the extent of tissue damage in this critical central nervous system region; and (2) investigate the magnitude of the correlation of cervical cord DT MRI metrics with patients' disability and tissue damage along the brain portion of the corticospinal tracts. Cervical cord and brain DT MRI scans were obtained from 28 patients with ALS and 20 age-matched and sex-matched controls. Cord mean diffusivity and fractional anisotropy histograms were produced and the cord cross-sectional area was measured. Average mean diffusivity and fractional anisotropy along the brain portion of the corticospinal tracts were also measured. Results: Compared with controls, patients with ALS had significantly lower mean fractional anisotropy (p = 0.002) and cord cross-sectional area (p",
author = "P. Valsasina and F. Agosta and B. Benedetti and D. Caputo and M. Perini and F. Salvi and A. Prelle and M. Filippi",
year = "2007",
month = "5",
doi = "10.1136/jnnp.2006.100032",
language = "English",
volume = "78",
pages = "480--484",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "5",

}

TY - JOUR

T1 - Diffusion anisotropy of the cervical cord is strictly associated with disability in amyotrophic lateral sclerosis

AU - Valsasina, P.

AU - Agosta, F.

AU - Benedetti, B.

AU - Caputo, D.

AU - Perini, M.

AU - Salvi, F.

AU - Prelle, A.

AU - Filippi, M.

PY - 2007/5

Y1 - 2007/5

N2 - Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with severe cervical cord damage due to degeneration of the corticospinal tracts and loss of lower motor neurones. Diffusion tensor magnetic resonance imaging (DT MRI) allows the measurement of quantities reflecting the size (such as mean diffusivity) and orientation (such as fractional anisotropy) of water-filled spaces in biological tissues. Methods: Mean diffusivity and fractional anisotropy histograms from the cervical cord of patients with ALS were obtained to: (1) quantify the extent of tissue damage in this critical central nervous system region; and (2) investigate the magnitude of the correlation of cervical cord DT MRI metrics with patients' disability and tissue damage along the brain portion of the corticospinal tracts. Cervical cord and brain DT MRI scans were obtained from 28 patients with ALS and 20 age-matched and sex-matched controls. Cord mean diffusivity and fractional anisotropy histograms were produced and the cord cross-sectional area was measured. Average mean diffusivity and fractional anisotropy along the brain portion of the corticospinal tracts were also measured. Results: Compared with controls, patients with ALS had significantly lower mean fractional anisotropy (p = 0.002) and cord cross-sectional area (p

AB - Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with severe cervical cord damage due to degeneration of the corticospinal tracts and loss of lower motor neurones. Diffusion tensor magnetic resonance imaging (DT MRI) allows the measurement of quantities reflecting the size (such as mean diffusivity) and orientation (such as fractional anisotropy) of water-filled spaces in biological tissues. Methods: Mean diffusivity and fractional anisotropy histograms from the cervical cord of patients with ALS were obtained to: (1) quantify the extent of tissue damage in this critical central nervous system region; and (2) investigate the magnitude of the correlation of cervical cord DT MRI metrics with patients' disability and tissue damage along the brain portion of the corticospinal tracts. Cervical cord and brain DT MRI scans were obtained from 28 patients with ALS and 20 age-matched and sex-matched controls. Cord mean diffusivity and fractional anisotropy histograms were produced and the cord cross-sectional area was measured. Average mean diffusivity and fractional anisotropy along the brain portion of the corticospinal tracts were also measured. Results: Compared with controls, patients with ALS had significantly lower mean fractional anisotropy (p = 0.002) and cord cross-sectional area (p

UR - http://www.scopus.com/inward/record.url?scp=34247181189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247181189&partnerID=8YFLogxK

U2 - 10.1136/jnnp.2006.100032

DO - 10.1136/jnnp.2006.100032

M3 - Article

VL - 78

SP - 480

EP - 484

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 5

ER -