Diffusion imaging study of the Corpus Callosum in bipolar disorder

Cecilia Prunas, Giuseppe Delvecchio, Cinzia Perlini, Marco Barillari, Mirella Ruggeri, A. Carlo Altamura, Marcella Bellani, Paolo Brambilla

Research output: Contribution to journalArticlepeer-review


Structural and diffusion imaging studies have provided some evidence of abnormal organization of Corpus Callosum (CC) in Bipolar Disorder (BD). Therefore, by using Diffusion Weighted Imaging (DWI), which allows to build subtle prediction models of fiber integrity for white matter (WM) tracts, this study aims to further explore the microstructure integrity of CC in BD patients compared to matched healthy controls. Twenty-four chronic patients with BD and 35 healthy controls were included in the study. Circular regions of interest were placed, on diffusion images, in the left and right side of callosal regions (i.e. rostrum/genu, anterior body, posterior body, splenium) and the Apparent Diffusion Coefficient (ADC) was then calculated. Significantly increased ADC values were found in right anterior body and in right splenium in BD patients compared to healthy controls (all p < 0.05, Bonferroni corrected). In this study, we found abnormally increased ADC callosal values in BD suggesting microstructural anomalies specifically in the right hemisphere. Interestingly, this finding further supports the presence of an altered inter-hemispheric communication between frontal and temporo-parietal association areas in patients with BD, which may ultimately result in clinical symptoms and cognitive deficits.

Original languageEnglish
Pages (from-to)75-81
JournalPsychiatry Research - Neuroimaging
Publication statusPublished - 2018


  • Bipolar Disorder
  • Corpus Callosum
  • Diffusion-weighted imaging
  • Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health


Dive into the research topics of 'Diffusion imaging study of the Corpus Callosum in bipolar disorder'. Together they form a unique fingerprint.

Cite this