Diffusion of water in large demyelinating lesions: A follow-up study

A. Castriota-Scanderbeg, U. Sabatini, F. Fasano, R. Floris, L. Fraracci, M. Di Mario, U. Nocentini, C. Caltagirone

Research output: Contribution to journalArticlepeer-review


We studied five patients with multiple sclerosis with one plaque of demyelination more than 2 cm in diameter, using conventional and diffusion-weighted MRI, soon after the onset of symptoms and over 1-36 months. The orientationally averaged diffusion coefficient <D > was increased in all the acute lesions, and increased further during follow-up in three. There was a strong correlation between <D > and the degree of low signal on T1-weighted images. The quantitative information provided by <D > allowed delineation of different diffusion patterns in large MS lesions, that may reflect heterogeneity of the anatomical substrate.

Original languageEnglish
Pages (from-to)764-767
Number of pages4
Issue number9
Publication statusPublished - 2002


  • Diffusion
  • Magnetic resonance imaging
  • Multiple sclerosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Radiological and Ultrasound Technology


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