Abstract
We studied five patients with multiple sclerosis with one plaque of demyelination more than 2 cm in diameter, using conventional and diffusion-weighted MRI, soon after the onset of symptoms and over 1-36 months. The orientationally averaged diffusion coefficient <D > was increased in all the acute lesions, and increased further during follow-up in three. There was a strong correlation between <D > and the degree of low signal on T1-weighted images. The quantitative information provided by <D > allowed delineation of different diffusion patterns in large MS lesions, that may reflect heterogeneity of the anatomical substrate.
Original language | English |
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Pages (from-to) | 764-767 |
Number of pages | 4 |
Journal | Neuroradiology |
Volume | 44 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2002 |
Keywords
- Diffusion
- Magnetic resonance imaging
- Multiple sclerosis
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Clinical Neurology
- Radiological and Ultrasound Technology