Diffusion of water in large demyelinating lesions: A follow-up study

A. Castriota-Scanderbeg; U. Sabatini; F. Fasano; R. Floris; L. Fraracci; M. Di Mario; U. Nocentini; C. Caltagirone

doi:10.1007/s00234-002-0806-y

Diffusion of water in large demyelinating lesions: A follow-up study

A. Castriota-Scanderbeg, U. Sabatini, F. Fasano, R. Floris, L. Fraracci, M. Di Mario, U. Nocentini, C. Caltagirone

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

We studied five patients with multiple sclerosis with one plaque of demyelination more than 2 cm in diameter, using conventional and diffusion-weighted MRI, soon after the onset of symptoms and over 1-36 months. The orientationally averaged diffusion coefficient <D > was increased in all the acute lesions, and increased further during follow-up in three. There was a strong correlation between <D > and the degree of low signal on T1-weighted images. The quantitative information provided by <D > allowed delineation of different diffusion patterns in large MS lesions, that may reflect heterogeneity of the anatomical substrate.

Original language	English
Pages (from-to)	764-767
Number of pages	4
Journal	Neuroradiology
Volume	44
Issue number	9
DOIs	https://doi.org/10.1007/s00234-002-0806-y
Publication status	Published - 2002

Keywords

Diffusion
Magnetic resonance imaging
Multiple sclerosis

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Clinical Neurology
Radiological and Ultrasound Technology

Access to Document

10.1007/s00234-002-0806-y

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abstract = "We studied five patients with multiple sclerosis with one plaque of demyelination more than 2 cm in diameter, using conventional and diffusion-weighted MRI, soon after the onset of symptoms and over 1-36 months. The orientationally averaged diffusion coefficient <D > was increased in all the acute lesions, and increased further during follow-up in three. There was a strong correlation between <D > and the degree of low signal on T1-weighted images. The quantitative information provided by <D > allowed delineation of different diffusion patterns in large MS lesions, that may reflect heterogeneity of the anatomical substrate.",

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AU - Castriota-Scanderbeg, A.

AU - Sabatini, U.

AU - Fasano, F.

AU - Floris, R.

AU - Fraracci, L.

AU - Di Mario, M.

AU - Nocentini, U.

AU - Caltagirone, C.

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AB - We studied five patients with multiple sclerosis with one plaque of demyelination more than 2 cm in diameter, using conventional and diffusion-weighted MRI, soon after the onset of symptoms and over 1-36 months. The orientationally averaged diffusion coefficient <D > was increased in all the acute lesions, and increased further during follow-up in three. There was a strong correlation between <D > and the degree of low signal on T1-weighted images. The quantitative information provided by <D > allowed delineation of different diffusion patterns in large MS lesions, that may reflect heterogeneity of the anatomical substrate.

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KW - Magnetic resonance imaging

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