Diffusion tensor and magnetization transfer MR imaging of early-onset multiple sclerosis

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Multiple sclerosis (MS) is a chronic, demyelinating disease of the central nervous system (CNS) with the onset of symptoms typically occurring between the age of 20 and 40 years. However, in about 3% to 12% of the cases, the onset of the disease is before 16 years of age. This review summarizes the main results obtained by the application of conventional and non-conventional MRI techniques to the assessment of patients with early-onset MS, which showed that the overall amount of CNS damage in these subjects is mild, compared to that typically detected in the adult-form of the disease. This fits with the notion that an early onset of the disease is associated with a more favourable clinical evolution.

Original languageEnglish
JournalNeurological Sciences
Issue numberSUPPL. 4
Publication statusPublished - Nov 2004


  • Diffusion weighted imaging
  • Early-onset multiple sclerosis
  • Magnetic resonance imaging
  • Magnetization transfer imaging

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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