Diffusion tensor imaging applications in multiple sclerosis patients using 3T magnetic resonance: A preliminary study

Lorenzo Testaverde, Laura Caporali, Eugenio Venditti, Giovanni Grillea, Claudio Colonnese

Research output: Contribution to journalArticlepeer-review


Objectives This study evaluated patients with multiple sclerosis using diffusion tensor imaging (DTI) to obtain fractional anisotropy (FA) and mean diffusivity (MD) values. Methods We investigated the possible statistically significant variation of MD and FA in different MS patients, compared simultaneously, putting in comparison their normal appearing white matter (NAWM) and white matter affected by disease (plaques), both during activity and in remission, with normal white matter (NWM) of control subjects. Results Statistical analysis using Levene's test for comparison of variances revealed significant (P0.05). Conclusion Imaging of MS using MRI techniques is constantly searching for reproducible quantitative parameter. This study shows how these parameters can be identified in the MD and FA values, and thus suggests the implementation of MRI routine protocols for diagnosing MS with the DTI analysis, since it can provide valuable information otherwise unobtainable. Key Points • Magnetic resonance imaging is widely performed in multiple sclerosis (MS) patients • Diffusion tensor imaging (DTI) can be implemented using a 3T magnet • DTI provides quantitative parameters as mean diffusivity (MD) and fractional anisotropy (FA) • MD and, especially, FA can help evaluate the lesion load in MS patients and also assess variation in normal appearing white matter (NAWM) in MS.

Original languageEnglish
Pages (from-to)990-997
Number of pages8
JournalEuropean Radiology
Issue number5
Publication statusPublished - May 2012


  • Diffusion tensor imaging
  • Fractional anisotropy
  • Magnetic resonance
  • Mean diffusivity
  • Multiple sclerosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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