Diffusion tensor imaging in multiple sclerosis: Correlations with clinical disability

M. Inglese, G. Iannucci, M. Cercignani, B. Colombo, G. Comi, M. Filippi

Research output: Contribution to journalArticlepeer-review


Introduction. Diffusion measurements inside biological tissues provide information about tissue configuration at a microscopic level, which are inaccessible to other magnetic resonance (MR) techniques. Objectives. To quantify, using diffusion tensor imaging (DTI), the damage of lesions and normal-appearing white matter (NAWM) from patients with multiple sclerosis (MS) and to investigate the magnitude of the correlation between DTI metrics and clinical disability. Methods. Conventional MR and DTI scans were obtained from 78 patients and 20 controls. After creating mean diffusivity (D) and fractional anisotropy (FA) maps, D and FA values were measured for 4846 lesions (3207 non-enhancing T1-isointense, 1511 nonenhancing T1-hypointense, and 128 enhancing), 497 NAWM areas from patients and 160 WM areas from controls. Results. The average lesion D was higher and the average lesion FA was lower than the corresponding quantities of the NAWM (P

Original languageEnglish
JournalNeurological Sciences
Issue number4 SUPPL.
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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