Diffusion tensor imaging of early changes in corpus callosum after acute cerebral hemisphere lesions in newborns

Andrea Righini, Chiara Doneda, Cecilia Parazzini, Filippo Arrigoni, Ursula Matta, Fabio Triulzi

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction The main purpose was to investigate any early diffusion tensor imaging (DTI) changes in corpus callosum (CC) associated with acute cerebral hemisphere lesions in term newborns. Methods We retrospectively analysed 19 cases of term newborns acutely affected by focal or multi-focal lesions: hypoxic-ischemic encephalopathy, hypoglycaemic encephalopathy,focal ischemic stroke and deep medullary vein associated lesions. DTI was acquired at 1.5 Tesla with dedicated neonatal coil. DTI metrics (apparent diffusion coefficient (ADC), fractional anisotropy (FA), axial λ|| and radial λ diffusivity) were measured in the hemisphere lesions and in the CC. The control group included seven normal newborns. Results The following significant differences were found between patients and normal controls in the CC: mean ADC was lower in patients (0.88 SD 0.23 versus 1.18 SD 0.07 μm2/s) and so was mean FA (0.50 SD 0.1 versus 0.67 SD 0.05) and mean λ|| value (1.61 SD 0.52 versus 2.36 SD0.14 μm 2/s). In CC the percentage of ADC always diminished independently of lesion age (with one exception), whereas in hemisphere lesions, it was negative in earlier lesions, but exceeded normal values in the older lesions. Conclusion CC may undergo early DTI changes in newborns with acute focal or multi-focal hemisphere lesions of different aetiology. Although a direct insult to CC cannot be totally ruled out, DTI changes in CC (in particular λ||) may also be compatible with very early Wallerian degeneration or pre-Wallerian degeneration.

Original languageEnglish
Pages (from-to)1025-1035
Number of pages11
JournalNeuroradiology
Volume52
Issue number11
DOIs
Publication statusPublished - Nov 2010

Keywords

  • Corpus callosum
  • Diffusion tensor imaging
  • Hypoxic-ischemic encephalopathy
  • Newborn
  • Wallerian degeneration

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Diffusion tensor imaging of early changes in corpus callosum after acute cerebral hemisphere lesions in newborns'. Together they form a unique fingerprint.

Cite this