Diffusion tensor magnetic resonance imaging tractography in progressive supranuclear palsy

Elisa Canu, Federica Agosta, Francesca Baglio, Sebastiano Galantucci, Raffaello Nemni, Massimo Filippi

Research output: Contribution to journalArticle

Abstract

Background:: Diffusion tensor magnetic resonance imaging tractography allows quantification of in vivo white matter tract damage. Methods:: Using tractography, diffusion tensor magnetic resonance imaging metrics were obtained from the superior and middle cerebellar peduncles and major cerebral white matter tracts in 5 patients with progressive supranuclear palsy and 13 controls. Results:: Patients showed severe intrinsic damage to the superior cerebellar peduncle, corpus callosum, and cingulum bilaterally. Only decreased axial diffusivity was found in the left middle cerebellar peduncle. Conclusions:: Diffusion tensor magnetic resonance imaging tractography holds promise for providing accurate in vivo cartography of progressive supranuclear palsy tissue damage.

Original languageEnglish
Pages (from-to)1751-1755
Number of pages5
JournalMovement Disorders
Volume26
Issue number9
DOIs
Publication statusPublished - Aug 1 2011

Keywords

  • Diffusion tensor magnetic resonance imaging
  • Progressive supranuclear palsy
  • Superior cerebellar peduncle
  • Tractography

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

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