TY - JOUR
T1 - Diffusion tensor MRI contributes to differentiate Richardson's syndrome from PSP-parkinsonism
AU - Agosta, Federica
AU - Pievani, Michela
AU - Svetel, Marina
AU - Ječmenica Lukić, Milica
AU - Copetti, Massimiliano
AU - Tomić, Aleksandra
AU - Scarale, Antonio
AU - Longoni, Giulia
AU - Comi, Giancarlo
AU - Kostić, Vladimir S.
AU - Filippi, Massimo
PY - 2012/12
Y1 - 2012/12
N2 - This study investigated the regional distribution of white matter (WM) damage in Richardson's syndrome (PSP-RS) and progressive supranuclear palsy-Parkinsonism (PSP-P) using diffusion tensor (DT) magnetic resonance imaging (MRI). The DT MRI classificatory ability in diagnosing progressive supranuclear palsy (PSP) syndromes, when used in combination with infratentorial volumetry, was also quantified. In 37 PSP (21 PSP-RS, 16 PSP-P) and 42 controls, the program Tract-Based Spatial Statistics (TBSS; www.fmrib.ox.ac.uk/fsl/tbss) was applied. DT MRI metrics were derived from supratentorial, thalamic, and infratentorial tracts. The magnetic resonance parkinsonism index (MRPI) was calculated. All PSP harbored diffusivity abnormalities in the corpus callosum, frontoparietal, and frontotemporo-occipital tracts. Infratentorial WM and thalamic radiations were severely affected in PSP-RS and relatively spared in PSP-P. When MRPI and DT MRI measures were combined, the discriminatory power increased for each comparison. Distinct patterns of WM alterations occur in PSP-RS and PSP-P. Adding DT MRI measures to MRPI improves the diagnostic accuracy in differentiating each PSP syndrome from healthy individuals and each other.
AB - This study investigated the regional distribution of white matter (WM) damage in Richardson's syndrome (PSP-RS) and progressive supranuclear palsy-Parkinsonism (PSP-P) using diffusion tensor (DT) magnetic resonance imaging (MRI). The DT MRI classificatory ability in diagnosing progressive supranuclear palsy (PSP) syndromes, when used in combination with infratentorial volumetry, was also quantified. In 37 PSP (21 PSP-RS, 16 PSP-P) and 42 controls, the program Tract-Based Spatial Statistics (TBSS; www.fmrib.ox.ac.uk/fsl/tbss) was applied. DT MRI metrics were derived from supratentorial, thalamic, and infratentorial tracts. The magnetic resonance parkinsonism index (MRPI) was calculated. All PSP harbored diffusivity abnormalities in the corpus callosum, frontoparietal, and frontotemporo-occipital tracts. Infratentorial WM and thalamic radiations were severely affected in PSP-RS and relatively spared in PSP-P. When MRPI and DT MRI measures were combined, the discriminatory power increased for each comparison. Distinct patterns of WM alterations occur in PSP-RS and PSP-P. Adding DT MRI measures to MRPI improves the diagnostic accuracy in differentiating each PSP syndrome from healthy individuals and each other.
KW - Atrophy
KW - Diffusion tensor MRI
KW - PSP-Parkinsonism
KW - Richardson's syndrome
UR - http://www.scopus.com/inward/record.url?scp=84866751693&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866751693&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2012.02.002
DO - 10.1016/j.neurobiolaging.2012.02.002
M3 - Article
C2 - 22418735
AN - SCOPUS:84866751693
VL - 33
SP - 2817
EP - 2826
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 12
ER -