Diffusion tensor MRI contributes to differentiate Richardson's syndrome from PSP-parkinsonism

Federica Agosta, Michela Pievani, Marina Svetel, Milica Ječmenica Lukić, Massimiliano Copetti, Aleksandra Tomić, Antonio Scarale, Giulia Longoni, Giancarlo Comi, Vladimir S. Kostić, Massimo Filippi

Research output: Contribution to journalArticlepeer-review


This study investigated the regional distribution of white matter (WM) damage in Richardson's syndrome (PSP-RS) and progressive supranuclear palsy-Parkinsonism (PSP-P) using diffusion tensor (DT) magnetic resonance imaging (MRI). The DT MRI classificatory ability in diagnosing progressive supranuclear palsy (PSP) syndromes, when used in combination with infratentorial volumetry, was also quantified. In 37 PSP (21 PSP-RS, 16 PSP-P) and 42 controls, the program Tract-Based Spatial Statistics (TBSS; www.fmrib.ox.ac.uk/fsl/tbss) was applied. DT MRI metrics were derived from supratentorial, thalamic, and infratentorial tracts. The magnetic resonance parkinsonism index (MRPI) was calculated. All PSP harbored diffusivity abnormalities in the corpus callosum, frontoparietal, and frontotemporo-occipital tracts. Infratentorial WM and thalamic radiations were severely affected in PSP-RS and relatively spared in PSP-P. When MRPI and DT MRI measures were combined, the discriminatory power increased for each comparison. Distinct patterns of WM alterations occur in PSP-RS and PSP-P. Adding DT MRI measures to MRPI improves the diagnostic accuracy in differentiating each PSP syndrome from healthy individuals and each other.

Original languageEnglish
Pages (from-to)2817-2826
Number of pages10
JournalNeurobiology of Aging
Issue number12
Publication statusPublished - Dec 2012


  • Atrophy
  • Diffusion tensor MRI
  • PSP-Parkinsonism
  • Richardson's syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology


Dive into the research topics of 'Diffusion tensor MRI contributes to differentiate Richardson's syndrome from PSP-parkinsonism'. Together they form a unique fingerprint.

Cite this