Abstract
Diffusion tensor magnetic resonance imaging (DT-MRI) is a powerful quantitative technique with the ability to detect in vivo microscopic characteristics and abnormalities of brain tissue. It has been successfully applied to a number of neurological conditions, such as stroke, multiple sclerosis and brain tumors, providing information otherwise inaccessible on the pathological substrates. DT-MRI has also been used to study patients with cognitive decline, mainly those with Alzheimer's disease. Several image-analysis approaches have been employed, including region of interest, histogram, voxel-based analyses and DT-MRI-based tractography. Specific patterns of spatial distribution of tissue damage and correlations with neuropsychological measures have been reported. This review focuses on the use of DT-MRI to investigate dementias. The main clinical results and the different methods of image analysis will be overviewed and discussed.
Original language | English |
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Pages (from-to) | 969-977 |
Number of pages | 9 |
Journal | Magnetic Resonance Imaging |
Volume | 25 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jul 2007 |
Keywords
- Alzheimer
- Dementia
- Diffusion
- Frontotemporal dementia
- Leukoaraiosis
- Lewy bodies
- MRI
- Tensor
ASJC Scopus subject areas
- Biophysics
- Clinical Biochemistry
- Structural Biology
- Radiology Nuclear Medicine and imaging
- Condensed Matter Physics