Diffusion tensor MRI to investigate dementias: a brief review

Marco Bozzali, Andrea Cherubini

Research output: Contribution to journalArticlepeer-review


Diffusion tensor magnetic resonance imaging (DT-MRI) is a powerful quantitative technique with the ability to detect in vivo microscopic characteristics and abnormalities of brain tissue. It has been successfully applied to a number of neurological conditions, such as stroke, multiple sclerosis and brain tumors, providing information otherwise inaccessible on the pathological substrates. DT-MRI has also been used to study patients with cognitive decline, mainly those with Alzheimer's disease. Several image-analysis approaches have been employed, including region of interest, histogram, voxel-based analyses and DT-MRI-based tractography. Specific patterns of spatial distribution of tissue damage and correlations with neuropsychological measures have been reported. This review focuses on the use of DT-MRI to investigate dementias. The main clinical results and the different methods of image analysis will be overviewed and discussed.

Original languageEnglish
Pages (from-to)969-977
Number of pages9
JournalMagnetic Resonance Imaging
Issue number6
Publication statusPublished - Jul 2007


  • Alzheimer
  • Dementia
  • Diffusion
  • Frontotemporal dementia
  • Leukoaraiosis
  • Lewy bodies
  • MRI
  • Tensor

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics


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