Diffusion weighted imaging and apparent diffusion coefficient in 3 tesla magnetic resonance imaging of breast lesions

Rocchina Caivano, Antonio Villonio, Felice D'Antuono, Matilde Gioioso, Paola Rabasco, Giancarlo Iannelli, Alexis Zandolino, Antonella Lotumolo, Giuseppina Dinardo, Luca Macarini, Giuseppe Guglielmi, Aldo Cammarota

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the utility of diffusion-weighted-imaging (DWI) and apparent-diffusion-coefficient (ADC) in a 3T magnetic-resonance-imaging (MRI) study of breast cancer. In particular, the study aims to classify ADC-values according to histology either for benign or malignant lesions. Methods: 110 Breast MRI with MRI-DWI sequences and quantitative evaluation of the ADC were retrospectively reviewed. Results obtained with MRI-DWI and with biopsy were analyzed and ADC values were compared to histological results. Results: MRI showed a 95.5% sensitivity and a 83.7% specificity. The mean ADC values of benign and malignant lesions were 2.06 ± 0.19 and 1.03 ± 0.07 mm/s, respectively (p <.05). Conclusions: DWI and ADC-values could help distinguishing malignant and benign breast masses.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalCancer Investigation
Volume33
Issue number5
DOIs
Publication statusPublished - May 28 2015

Keywords

  • 3T magnetic resonance imaging
  • Apparent diffusion coefficient
  • Breast cancer
  • Diffusion weighted imaging

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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  • Cite this

    Caivano, R., Villonio, A., D'Antuono, F., Gioioso, M., Rabasco, P., Iannelli, G., Zandolino, A., Lotumolo, A., Dinardo, G., Macarini, L., Guglielmi, G., & Cammarota, A. (2015). Diffusion weighted imaging and apparent diffusion coefficient in 3 tesla magnetic resonance imaging of breast lesions. Cancer Investigation, 33(5), 159-164. https://doi.org/10.3109/07357907.2015.1019674