Diffusion-weighted imaging and fluid-attenuated inversion recovery sequence in sporadic Creutzfeldt-Jakob disease

Rosa Morabito, Annalisa Baglieri, Rosella Ciurleo, Francesco Corallo, Rosaria de Luca, Simona de Salvo, Silvia Guerrera, Francesca Timpano, Maria Adele Marino, Placido Bramanti, Silvia Marino

Research output: Contribution to journalArticlepeer-review

Abstract

The diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) is extremely difficult. Diffusion-weighted imaging has been shown to be the most sensitive technique for the detection of signal alterations in sCJD patients. The present study analyzed the diagnostic value of diffusion-weighted imaging and fluid-attenuated inversion recovery sequence in the early stage of sCJD in one female patient and correlated the clinical symptoms during disease course and magnetic resonance manifestations. Thalamic and basal ganglia hyperintensities were observed on magnetic resonance images in a very early stage, i.e., when the clinical typical manifestations of the disease were not present. With the progression of the disease, cortical and basal ganglia hyperintensities were observed on magnetic resonance images, showing an obvious cerebral atrophy. These findings suggest that diffusion-weighted imaging and fluid-attenuated inversion recovery sequence are helpful in diagnosing sCJD.

Original languageEnglish
Pages (from-to)2295-2297
Number of pages3
JournalNeural Regeneration Research
Volume6
Issue number29
DOIs
Publication statusPublished - 2011

Keywords

  • Creutzfeldt-Jacob disease
  • Diffusion-weighted imaging
  • Fluid-attenuated inversion recovery
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Developmental Neuroscience

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