Diffusion-weighted imaging predicts cognitive impairment in multiple sclerosis

Ralph H B Benedict, Jared Bruce, Michael G. Dwyer, Bianca Weinstock-Guttman, Chris Tjoa, Eleonora Tavazzi, Frederick E. Munschauer, Robert Zivadinov

Research output: Contribution to journalArticle

Abstract

Following a previous study with diffusion tensor imaging, we investigated the correlation between diffusion-weighted imaging (DWI) and cognitive dysfunction in multiple sclerosis (MS). We studied 60 MS patients (mean age 45.8 ± 9.0 years) using 1.5-T MRI. Disease course was RR=40 and SP=20. Mean disease duration was 12.8 ± 8.7 years. Mean EDSS was 3.4 ± 1.7. Whole brain, gray and white matter normalized volumes were calculated on 3D SPGRT1-WI using a fully automated Hybrid SIENAX method. Parenchymal mean diffusivity (PMD) maps were created after automated segmentation of the brain parenchyma and cerebrospinal fluid using T2-WI and DW images. Histogram analysis was performed and DWI indices of peak position (PP), peak height (PH), mean parenchymal diffusivity (MPD) and entropy were obtained. Neuropsychological (NP) evaluation emphasized auditory/verbal and visual/ spatial memory, as well as processing speed and executive function. We found significant correlations between DWI and performance in all cognitive domains. Overall, stronger correlations emerged for MPD and entropy than other DWI measures, although all correlations were in the expected direction. The strongest association was between DWI entropy and performance on the Symbol Digit Modalities Test, which assesses processing speed and working memory (r = -0.54). Fisher r to z transformations revealed that DWI, gray matter (GMF) and whole brain (BPF) atrophy, T1 -lesion volume (LV) and T2-LV all accounted for similar amounts of variance in NP testing. Stepwise regression models determined whether multiple MRI measures predicted unique additive variance in test performance. GMF (R2=0.35, F=30.82, P <0.01) and entropy (ΔR2 = 0.06, ΔF = 5.47, P <0.05) both accounted for unique variance in processing speed. Our data make a stronger case for the clinical validity of DWI in MS than heretofore reported. DWI has very short acquisition times, and the segmentation method applied in the present study is reliable and fully automated. Given its overall simplicity and moderate correlation with cognition, DWI may offer several logistic advantages over more traditional MRI measures when predicting the presence of NP impairment.

Original languageEnglish
Pages (from-to)722-730
Number of pages9
JournalMultiple Sclerosis Journal
Volume13
Issue number6
DOIs
Publication statusPublished - Jul 2007

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Multiple Sclerosis
Entropy
Glia Maturation Factor
Brain
Cognitive Dysfunction
Diffusion Tensor Imaging
Executive Function
Short-Term Memory
Cognition
Atrophy
Cerebrospinal Fluid

Keywords

  • Cognition
  • Diffusion-weighted imaging
  • Magnetic resonance imaging
  • Multiple sclerosis
  • Neuropsychology

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Benedict, R. H. B., Bruce, J., Dwyer, M. G., Weinstock-Guttman, B., Tjoa, C., Tavazzi, E., ... Zivadinov, R. (2007). Diffusion-weighted imaging predicts cognitive impairment in multiple sclerosis. Multiple Sclerosis Journal, 13(6), 722-730. https://doi.org/10.1177/1352458507075592

Diffusion-weighted imaging predicts cognitive impairment in multiple sclerosis. / Benedict, Ralph H B; Bruce, Jared; Dwyer, Michael G.; Weinstock-Guttman, Bianca; Tjoa, Chris; Tavazzi, Eleonora; Munschauer, Frederick E.; Zivadinov, Robert.

In: Multiple Sclerosis Journal, Vol. 13, No. 6, 07.2007, p. 722-730.

Research output: Contribution to journalArticle

Benedict, RHB, Bruce, J, Dwyer, MG, Weinstock-Guttman, B, Tjoa, C, Tavazzi, E, Munschauer, FE & Zivadinov, R 2007, 'Diffusion-weighted imaging predicts cognitive impairment in multiple sclerosis', Multiple Sclerosis Journal, vol. 13, no. 6, pp. 722-730. https://doi.org/10.1177/1352458507075592
Benedict RHB, Bruce J, Dwyer MG, Weinstock-Guttman B, Tjoa C, Tavazzi E et al. Diffusion-weighted imaging predicts cognitive impairment in multiple sclerosis. Multiple Sclerosis Journal. 2007 Jul;13(6):722-730. https://doi.org/10.1177/1352458507075592
Benedict, Ralph H B ; Bruce, Jared ; Dwyer, Michael G. ; Weinstock-Guttman, Bianca ; Tjoa, Chris ; Tavazzi, Eleonora ; Munschauer, Frederick E. ; Zivadinov, Robert. / Diffusion-weighted imaging predicts cognitive impairment in multiple sclerosis. In: Multiple Sclerosis Journal. 2007 ; Vol. 13, No. 6. pp. 722-730.
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