Abstract
The pathophysiology of essential tremor (ET) is unknown. PET and fMRI studies have revealed bilateral activation and 1H-MRS studies metabolic abnormalities in the cerebellum and other functionally related brain structures in ET. Diffusion-weighted imaging (DWI) was used to search for evidence of tissue integrity abnormalities in these areas in ET patients and 10 matched controls by calculating water apparent diffusion coefficients (ADCs). Regions of interest included the left and right cerebellum, red nucleus, thalamus, caudate, putamen, pallidum, and frontal white matter. Histograms of ADCs were generated for all pixels in the infratentorial compartment and manually segmented areas corresponding to brainstem, vermis, and cerebellar hemispheres. ADC values were similar in all brain areas in patients and controls. Our study did not detect changes affecting the investigated brain regions in ET patients. These findings argue against major structural damage in the ET brain, although more subtle neurodegenerative changes cannot be ruled out.
| Original language | English |
|---|---|
| Pages (from-to) | 1182-1185 |
| Number of pages | 4 |
| Journal | Movement Disorders |
| Volume | 22 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Jun 15 2007 |
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Keywords
- Apparent diffusion coefficient
- Cerebellum
- Diffusion-weighted imaging
- Essential tremor
- Neurodegeneration
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Diffusion-weighted imaging study of patients with essential tremor. / Martinelli, Paolo; Rizzo, Giovanni; Manners, David; Tonon, Caterina; Pizza, Fabio; Testa, Claudia; Scaglione, Cesa; Barbiroli, Bruno; Lodi, Raffaele.
In: Movement Disorders, Vol. 22, No. 8, 15.06.2007, p. 1182-1185.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diffusion-weighted imaging study of patients with essential tremor
AU - Martinelli, Paolo
AU - Rizzo, Giovanni
AU - Manners, David
AU - Tonon, Caterina
AU - Pizza, Fabio
AU - Testa, Claudia
AU - Scaglione, Cesa
AU - Barbiroli, Bruno
AU - Lodi, Raffaele
PY - 2007/6/15
Y1 - 2007/6/15
N2 - The pathophysiology of essential tremor (ET) is unknown. PET and fMRI studies have revealed bilateral activation and 1H-MRS studies metabolic abnormalities in the cerebellum and other functionally related brain structures in ET. Diffusion-weighted imaging (DWI) was used to search for evidence of tissue integrity abnormalities in these areas in ET patients and 10 matched controls by calculating water apparent diffusion coefficients (ADCs). Regions of interest included the left and right cerebellum, red nucleus, thalamus, caudate, putamen, pallidum, and frontal white matter. Histograms of ADCs were generated for all pixels in the infratentorial compartment and manually segmented areas corresponding to brainstem, vermis, and cerebellar hemispheres. ADC values were similar in all brain areas in patients and controls. Our study did not detect changes affecting the investigated brain regions in ET patients. These findings argue against major structural damage in the ET brain, although more subtle neurodegenerative changes cannot be ruled out.
AB - The pathophysiology of essential tremor (ET) is unknown. PET and fMRI studies have revealed bilateral activation and 1H-MRS studies metabolic abnormalities in the cerebellum and other functionally related brain structures in ET. Diffusion-weighted imaging (DWI) was used to search for evidence of tissue integrity abnormalities in these areas in ET patients and 10 matched controls by calculating water apparent diffusion coefficients (ADCs). Regions of interest included the left and right cerebellum, red nucleus, thalamus, caudate, putamen, pallidum, and frontal white matter. Histograms of ADCs were generated for all pixels in the infratentorial compartment and manually segmented areas corresponding to brainstem, vermis, and cerebellar hemispheres. ADC values were similar in all brain areas in patients and controls. Our study did not detect changes affecting the investigated brain regions in ET patients. These findings argue against major structural damage in the ET brain, although more subtle neurodegenerative changes cannot be ruled out.
KW - Apparent diffusion coefficient
KW - Cerebellum
KW - Diffusion-weighted imaging
KW - Essential tremor
KW - Neurodegeneration
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UR - http://www.scopus.com/inward/citedby.url?scp=34447558147&partnerID=8YFLogxK
U2 - 10.1002/mds.21287
DO - 10.1002/mds.21287
M3 - Article
C2 - 17469200
AN - SCOPUS:34447558147
VL - 22
SP - 1182
EP - 1185
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
IS - 8
ER -