Diffusion-weighted imaging study of patients with essential tremor

Paolo Martinelli, Giovanni Rizzo, David Manners, Caterina Tonon, Fabio Pizza, Claudia Testa, Cesa Scaglione, Bruno Barbiroli, Raffaele Lodi

Research output: Contribution to journalArticlepeer-review


The pathophysiology of essential tremor (ET) is unknown. PET and fMRI studies have revealed bilateral activation and 1H-MRS studies metabolic abnormalities in the cerebellum and other functionally related brain structures in ET. Diffusion-weighted imaging (DWI) was used to search for evidence of tissue integrity abnormalities in these areas in ET patients and 10 matched controls by calculating water apparent diffusion coefficients (ADCs). Regions of interest included the left and right cerebellum, red nucleus, thalamus, caudate, putamen, pallidum, and frontal white matter. Histograms of ADCs were generated for all pixels in the infratentorial compartment and manually segmented areas corresponding to brainstem, vermis, and cerebellar hemispheres. ADC values were similar in all brain areas in patients and controls. Our study did not detect changes affecting the investigated brain regions in ET patients. These findings argue against major structural damage in the ET brain, although more subtle neurodegenerative changes cannot be ruled out.

Original languageEnglish
Pages (from-to)1182-1185
Number of pages4
JournalMovement Disorders
Issue number8
Publication statusPublished - Jun 15 2007


  • Apparent diffusion coefficient
  • Cerebellum
  • Diffusion-weighted imaging
  • Essential tremor
  • Neurodegeneration

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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