Diffusion-weighted imaging tractography-based parcellation of the human lateral premotor cortex identifies dorsal and ventral subregions with anatomical and functional specializations

Valentina Tomassini, Saad Jbabdi, Johannes C. Klein, Timothy E J Behrens, Carlo Pozzilli, Paul M. Matthews, Matthew F S Rushworth, Heidi Johansen-Berg

Research output: Contribution to journalArticle

227 Citations (Scopus)

Abstract

Lateral premotor cortex (PM) in the macaque monkey can be segregated into structurally and functionally distinct subregions, including a major division between dorsal (PMd) and ventral (PMv) parts, which have distinct cytoarchitecture, function, and patterns of connectivity with both frontal and parietal cortical areas. The borders of their subregions are less well defined in the human brain. Here we use diffusion tractography to identify a reproducible border between dorsal and ventral subregions of human precentral gyrus. We derive connectivity fingerprints for the two subregions and demonstrate that each has a distinctive pattern of connectivity with frontal cortex and lateral parietal cortex, suggesting that these areas correspond to human PMd and PMv. Although putative human PMd has a high probability of connection with the superior parietal lobule, dorsal prefrontal cortex, and cingulate cortex, human PMv has a higher probability of connection with the anterior inferior parietal lobule and ventral prefrontal cortex. Finally, we assess the correspondence between our PMd/PMv border and local sulcal and functional anatomy. The location of the border falls at the level of the gyral branch that divides the inferior precentral sulcus from the superior precentral sulcus and corresponded closely to the location of a functional border defined using previous functional magnetic resonance imaging studies. Copyright

Original languageEnglish
Pages (from-to)10259-10269
Number of pages11
JournalJournal of Neuroscience
Volume27
Issue number38
DOIs
Publication statusPublished - Sep 19 2007

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Motor Cortex
Parietal Lobe
Frontal Lobe
Prefrontal Cortex
Diffusion Tensor Imaging
Gyrus Cinguli
Dermatoglyphics
Macaca
Haplorhini
Anatomy
Magnetic Resonance Imaging
Brain

Keywords

  • Diffusion imaging
  • Human
  • Parietal cortex
  • Prefrontal cortex
  • Premotor cortex
  • Tractography

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Diffusion-weighted imaging tractography-based parcellation of the human lateral premotor cortex identifies dorsal and ventral subregions with anatomical and functional specializations. / Tomassini, Valentina; Jbabdi, Saad; Klein, Johannes C.; Behrens, Timothy E J; Pozzilli, Carlo; Matthews, Paul M.; Rushworth, Matthew F S; Johansen-Berg, Heidi.

In: Journal of Neuroscience, Vol. 27, No. 38, 19.09.2007, p. 10259-10269.

Research output: Contribution to journalArticle

Tomassini, Valentina ; Jbabdi, Saad ; Klein, Johannes C. ; Behrens, Timothy E J ; Pozzilli, Carlo ; Matthews, Paul M. ; Rushworth, Matthew F S ; Johansen-Berg, Heidi. / Diffusion-weighted imaging tractography-based parcellation of the human lateral premotor cortex identifies dorsal and ventral subregions with anatomical and functional specializations. In: Journal of Neuroscience. 2007 ; Vol. 27, No. 38. pp. 10259-10269.
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