Abstract
Background: Endoscopy and imaging objectively assess Crohn's disease (CD) activity. Magnetic resonance enterography (MRE) uses no ionizing radiation, carries no significant morbidity, and is highly sensitive in revealing soft tissues inflammation. Diffusion-weighted imaging can distinguish intestinal inflammation from a lower diffusion of water molecules giving rise to a reduced apparent diffusion coefficient. The magnetic resonance index of activity score and, more recently, the Clermont score were recently developed for staging CD activity. The aim of this study was to compare the MRE scores and the Simple Endoscopic Score for CD in identifying ileal CD activity. Methods: Fifty-five patients with ileal and ileocolonic CD were consecutively enrolled between June 2012 and June 2013. All patients underwent clinical examination, biochemical tests, MRE, and colonoscopy to assess disease activity. Results: MRE assessed active ileal disease in 31 patients (56.3%). The Clermont score significantly correlated with the magnetic resonance index of activity score (r = 0.91; P <0.0001) and the Simple Endoscopic Score for CD (r = 0.76; P <0.0001). The apparent diffusion coefficient correlated with the Simple Endoscopic Score for CD (r = 20.63; P <0.0001) especially in unoperated patients. Conclusions: The Clermont score and the apparent diffusion coefficient value can stage ileal CD, avoiding the need to use contrast agents.
| Original language | English |
|---|---|
| Pages (from-to) | 1575-1583 |
| Number of pages | 9 |
| Journal | Inflammatory Bowel Diseases |
| Volume | 20 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Dec 1 2014 |
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Keywords
- ADC and clermont
- Crohn's disease
- Diffusion-weighted imaging
- Magnetic resonance imaging
- MaRIA
ASJC Scopus subject areas
- Gastroenterology
- Immunology and Allergy
- Medicine(all)
Cite this
Diffusion-weighted magnetic resonance for assessing ileal Crohn's disease activity. / Caruso, Antonino; D'Incà, Renata; Scarpa, Marco; Manfrin, Paolo; Rudatis, Massimo; Pozza, Anna; Angriman, Imerio; Buda, Andrea; Sturniolo, Giacomo Carlo; Lacognata, Carmelo.
In: Inflammatory Bowel Diseases, Vol. 20, No. 9, 01.12.2014, p. 1575-1583.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diffusion-weighted magnetic resonance for assessing ileal Crohn's disease activity
AU - Caruso, Antonino
AU - D'Incà, Renata
AU - Scarpa, Marco
AU - Manfrin, Paolo
AU - Rudatis, Massimo
AU - Pozza, Anna
AU - Angriman, Imerio
AU - Buda, Andrea
AU - Sturniolo, Giacomo Carlo
AU - Lacognata, Carmelo
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Background: Endoscopy and imaging objectively assess Crohn's disease (CD) activity. Magnetic resonance enterography (MRE) uses no ionizing radiation, carries no significant morbidity, and is highly sensitive in revealing soft tissues inflammation. Diffusion-weighted imaging can distinguish intestinal inflammation from a lower diffusion of water molecules giving rise to a reduced apparent diffusion coefficient. The magnetic resonance index of activity score and, more recently, the Clermont score were recently developed for staging CD activity. The aim of this study was to compare the MRE scores and the Simple Endoscopic Score for CD in identifying ileal CD activity. Methods: Fifty-five patients with ileal and ileocolonic CD were consecutively enrolled between June 2012 and June 2013. All patients underwent clinical examination, biochemical tests, MRE, and colonoscopy to assess disease activity. Results: MRE assessed active ileal disease in 31 patients (56.3%). The Clermont score significantly correlated with the magnetic resonance index of activity score (r = 0.91; P <0.0001) and the Simple Endoscopic Score for CD (r = 0.76; P <0.0001). The apparent diffusion coefficient correlated with the Simple Endoscopic Score for CD (r = 20.63; P <0.0001) especially in unoperated patients. Conclusions: The Clermont score and the apparent diffusion coefficient value can stage ileal CD, avoiding the need to use contrast agents.
AB - Background: Endoscopy and imaging objectively assess Crohn's disease (CD) activity. Magnetic resonance enterography (MRE) uses no ionizing radiation, carries no significant morbidity, and is highly sensitive in revealing soft tissues inflammation. Diffusion-weighted imaging can distinguish intestinal inflammation from a lower diffusion of water molecules giving rise to a reduced apparent diffusion coefficient. The magnetic resonance index of activity score and, more recently, the Clermont score were recently developed for staging CD activity. The aim of this study was to compare the MRE scores and the Simple Endoscopic Score for CD in identifying ileal CD activity. Methods: Fifty-five patients with ileal and ileocolonic CD were consecutively enrolled between June 2012 and June 2013. All patients underwent clinical examination, biochemical tests, MRE, and colonoscopy to assess disease activity. Results: MRE assessed active ileal disease in 31 patients (56.3%). The Clermont score significantly correlated with the magnetic resonance index of activity score (r = 0.91; P <0.0001) and the Simple Endoscopic Score for CD (r = 0.76; P <0.0001). The apparent diffusion coefficient correlated with the Simple Endoscopic Score for CD (r = 20.63; P <0.0001) especially in unoperated patients. Conclusions: The Clermont score and the apparent diffusion coefficient value can stage ileal CD, avoiding the need to use contrast agents.
KW - ADC and clermont
KW - Crohn's disease
KW - Diffusion-weighted imaging
KW - Magnetic resonance imaging
KW - MaRIA
UR - http://www.scopus.com/inward/record.url?scp=84925861234&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925861234&partnerID=8YFLogxK
U2 - 10.1097/MIB.0000000000000128
DO - 10.1097/MIB.0000000000000128
M3 - Article
C2 - 25025715
AN - SCOPUS:84925861234
VL - 20
SP - 1575
EP - 1583
JO - Inflammatory Bowel Diseases
JF - Inflammatory Bowel Diseases
SN - 1078-0998
IS - 9
ER -