Diffusion-weighted magnetic resonance imaging in patients selected for radical cystectomy: Detection rate of pelvic lymph node metastases

Rocco Papalia, Giuseppe Simone, Rosario Grasso, Raffaele Augelli, Eliodoro Faiella, Salvatore Guaglianone, Roberto Cazzato, Riccardo Del Vescovo, Mariaconsiglia Ferriero, Bruno Zobel, Michele Gallucci

Research output: Contribution to journalArticlepeer-review

Abstract

Objective • To evaluate whether DW-MRI improves the detection of pelvic lymph nodes metastates in patients with bladder cancer undergoing radical cystectomy. Patients and Methods • 36 patients with CT scan negative for nodal metastates underwent DW-MRI before surgery. Diagnostic accuracy of DW-MRI was compared with histopathological findings. Results • Mean ADC value was 0.85 × 10 -3 mm 3/s in the nodal metastatic group and 1 × 10 -3 mm 3/s in the nodal non-metastatic group (P = 0.02). • The ADC cut-off value, obtained by the ROC curve was 0.86 × 10 -3 mm 3/s. • Patient-based sensitivity, specificity and positive and negative predictive values were 76.4%, 89.4%, 26.6%, and 71.4%, respectively. Conclusions • DW-MRI may be used to differentiate metastatic from non-metastatic lymph nodes in patients with high-grade bladder cancer.

Original languageEnglish
Pages (from-to)1031-1036
Number of pages6
JournalBJU International
Volume109
Issue number7
DOIs
Publication statusPublished - Apr 2012

Keywords

  • bladder cancer
  • diffusion weighted MRI
  • extended pelvic lymphadenectomy
  • lymph node metastasis

ASJC Scopus subject areas

  • Urology

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