Diffusion-weighted magnetic resonance imaging in patients with partial status epilepticus

Carlo Di Bonaventura, Francesca Bonini, Jinane Fattouch, Francesco Mari, Simona Petrucci, Marco Carnì, Emanuele Tinelli, Patrizia Pantano, Stefano Bastianello, Bruno Maraviglia, Mario Manfredi, Massimiliano Prencipe, Anna T. Giallonardo

Research output: Contribution to journalArticle

Abstract

Purpose: Diffusion-weighted magnetic resonance imaging (DWI) is used to detect changes in the distribution of water molecules in regions affected by various pathologies. Like other conditions, ictal epileptic activity, such as status epilepticus (SE), can cause regional vasogenic/cytotoxic edema that reflects hemodynamic and metabolic changes. This study describes the electroclinical and neuroimaging findings in 10 patients with partial SE whose DWI evaluation disclosed periictal changes related to sustained epileptic activity. Patients and Methods: In this retrospective study we selected 10 patients with partial SE of different etiologies (six acute symptomatic SE; four with previous epilepsy and concomitant precipitating factors) who underwent video-EEG (electroencephalography) monitoring and a DWI study during the periictal phase. We analyzed ictal electroclinical features and DWI changes in the acute phase and during the follow-up period. Results: DWI images revealed significant signal alterations in different brain regions depending on the location of ictal activity. DWI changes were highly concordant with the electroclinical findings in all 10 patients. As the SE resolved and the clinical conditions improved, DWI follow-up showed that the signal alterations gradually disappeared, thereby documenting their close relationship with ictal activity. Conclusions: This study confirms the usefulness of DWI imaging in clinical practice for a more accurate definition of the hemodynamic/metabolic changes occurring during sustained epileptic activity.

Original languageEnglish
Pages (from-to)45-52
Number of pages8
JournalEpilepsia
Volume50
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Jan 2009

Keywords

  • DWI
  • Epilepsy
  • Neuroimaging
  • Status epilepticus

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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  • Cite this

    Di Bonaventura, C., Bonini, F., Fattouch, J., Mari, F., Petrucci, S., Carnì, M., Tinelli, E., Pantano, P., Bastianello, S., Maraviglia, B., Manfredi, M., Prencipe, M., & Giallonardo, A. T. (2009). Diffusion-weighted magnetic resonance imaging in patients with partial status epilepticus. Epilepsia, 50(SUPPL. 1), 45-52. https://doi.org/10.1111/j.1528-1167.2008.01970.x