Imaging pesato in diffusione per la valutazione della risposta a terapie non chirurgiche del tumore della cervice uterina

Translated title of the contribution: Diffusion-weighted MR imaging in assessing cervical tumour response to nonsurgical therapy

S. Rizzo, P. Summers, S. Raimondi, M. Belmonte, M. Maniglio, F. Landoni, N. Colombo, M. Bellomi

Research output: Contribution to journalArticlepeer-review


Purpose: This study was undertaken to assess whether there is a correlation between the response of cervical tumours to nonsurgical therapy (chemo- and/or radiotherapy) and apparent diffusion coefficient (ADC) values. Patients and methods: Seventeen consecutive patients prospectively underwent pelvic magnetic resonance (MR) imaging including diffusion-weighted imaging (DWI) sequences before and after nonsurgical therapy for cervical cancer. A control group of 17 patients without cervical pathology was matched to the study group. Differences in baseline ADC maps between the two groups and within the study group before and after therapy were assessed by nonparametric tests. Results: The diameter and volume of cervical cancers decreased after therapy in 14/17 lesions (responders) and increased in 3/17 lesions (nonresponders). The ADC values of responders increased significantly (p=0.0009). Percent changes in ADC values before and after therapy were higher in responders than nonresponders (p=0.04). There was no significant difference in ADC values between responders and nonresponders at the staging MR examination (p=0.09) and no significant correlation between pretreatment ADC values and percentage of tumour reduction. Tumours with higher percent ADC value increase showed higher tumour reduction volume, but this was not significant (p=0.12). Conclusions: ADC values of cervical cancer after therapy showed significant differences compared with pretherapy values, particularly for responders.

Translated title of the contributionDiffusion-weighted MR imaging in assessing cervical tumour response to nonsurgical therapy
Original languageItalian
Pages (from-to)766-780
Number of pages15
JournalRadiologia Medica
Issue number5
Publication statusPublished - Aug 2011

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)


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