Diffusion-Weighted MR Imaging in the Evaluation of Renal Tumours

Ettore Squillaci, G. Manenti, F. Di Stefano, R. Miano, L. Strigari, G. Simonetti

Research output: Contribution to journalArticle

Abstract

The aim of this study was to evaluate the capability and the reliability of diffusion-weighted MR imaging to differentiate benign from malignant renal lesions. Twenty healthy volunteers and 48 patients with known renal lesions underwent MR of the kidneys by using a 1.5 T superconductive magnet. Diffusion-weighted images (DWI) were obtained on the axial plane during breath-hold (17 s) with a SE EPI single shot sequence using a b value of 500 s/mm2. One region of interest (ROI) (lesions<than 3 cm) or 3 ROI (lesions > than 3 cm) were placed within the lesion for the measurement of apparent diffusion coefficient (ADC). ADC map was obtained at each slice position. Mean ADC value in normal renal parenchyma was 2.2± 0.20 × 10-3 mm2/s, while ADC values in simple cysts (n=20) were higher (mean ADC values 3.65±0.09 × 10-3 mm2/S). Solid benign and malignant renal tumors (n=19) showed a mean ADC value of 1.7±0.48 × 10-3 mm2/sec. The comparison between ADC values in normal parenchyma group and tumour group were found to be statistically significant (p

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalJournal of Experimental and Clinical Cancer Research
Volume23
Issue number1
Publication statusPublished - Mar 2004

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Kidney
Neoplasms
Reference Values
Magnets
Cysts
Healthy Volunteers

Keywords

  • Diffusion study
  • Kidney
  • Magnetic resonance (MR)
  • Tumours

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Squillaci, E., Manenti, G., Di Stefano, F., Miano, R., Strigari, L., & Simonetti, G. (2004). Diffusion-Weighted MR Imaging in the Evaluation of Renal Tumours. Journal of Experimental and Clinical Cancer Research, 23(1), 39-45.

Diffusion-Weighted MR Imaging in the Evaluation of Renal Tumours. / Squillaci, Ettore; Manenti, G.; Di Stefano, F.; Miano, R.; Strigari, L.; Simonetti, G.

In: Journal of Experimental and Clinical Cancer Research, Vol. 23, No. 1, 03.2004, p. 39-45.

Research output: Contribution to journalArticle

Squillaci, E, Manenti, G, Di Stefano, F, Miano, R, Strigari, L & Simonetti, G 2004, 'Diffusion-Weighted MR Imaging in the Evaluation of Renal Tumours', Journal of Experimental and Clinical Cancer Research, vol. 23, no. 1, pp. 39-45.
Squillaci, Ettore ; Manenti, G. ; Di Stefano, F. ; Miano, R. ; Strigari, L. ; Simonetti, G. / Diffusion-Weighted MR Imaging in the Evaluation of Renal Tumours. In: Journal of Experimental and Clinical Cancer Research. 2004 ; Vol. 23, No. 1. pp. 39-45.
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