Diffusion-Weighted MR Imaging in the Evaluation of Renal Tumours

Ettore Squillaci, G. Manenti, F. Di Stefano, R. Miano, L. Strigari, G. Simonetti

Research output: Contribution to journalArticlepeer-review


The aim of this study was to evaluate the capability and the reliability of diffusion-weighted MR imaging to differentiate benign from malignant renal lesions. Twenty healthy volunteers and 48 patients with known renal lesions underwent MR of the kidneys by using a 1.5 T superconductive magnet. Diffusion-weighted images (DWI) were obtained on the axial plane during breath-hold (17 s) with a SE EPI single shot sequence using a b value of 500 s/mm2. One region of interest (ROI) (lesions<than 3 cm) or 3 ROI (lesions > than 3 cm) were placed within the lesion for the measurement of apparent diffusion coefficient (ADC). ADC map was obtained at each slice position. Mean ADC value in normal renal parenchyma was 2.2± 0.20 × 10-3 mm2/s, while ADC values in simple cysts (n=20) were higher (mean ADC values 3.65±0.09 × 10-3 mm2/S). Solid benign and malignant renal tumors (n=19) showed a mean ADC value of 1.7±0.48 × 10-3 mm2/sec. The comparison between ADC values in normal parenchyma group and tumour group were found to be statistically significant (p

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalJournal of Experimental and Clinical Cancer Research
Issue number1
Publication statusPublished - Mar 2004


  • Diffusion study
  • Kidney
  • Magnetic resonance (MR)
  • Tumours

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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