Diginyc partial hydatidiform mole with increased fetal nuchal translucency and ovarian hyperstimulation syndrome

Chiara Roberta Gaggero, Stefano Bogliolo, Paolo Sala, C. Molinari, S. Motzo, Ezio Fulcheri, Paola Anserini, Pierangela De Biasio

Research output: Contribution to journalArticle

Abstract

Purpose of investigation: Hydatidiform mole (HM) is an abnormal pregnancy characterized by proliferation of cytotrophoblast and syncytiotrophoblast and vesicular swelling of placental villi. The fetus or embryo can be absent or abnormal. HMs can be complete or partial. Case Report: A case of diginyc partial HM at 12 weeks of gestational age was referred to the present center of prenatal diagnosis. The patient showed ovarian hyperstimulation syndrome. At ultrasonography, increased fetal nuchal translucency (NT) with fetal anomaly was evident, without sonographic signs of placental mole. Pregnancy was terminated with legal abortion. Results: Partial HM (PHM) was suspected by ultrasonographic fetal markers with ovarian hyperstimulation syndrome, but the diagnosis was performed only with fluorescent in situ hybridization. In particular fetal NT appeared increased also in diginyc mole. Conclusion: In order to improve the detection rate of PHM, routine histological examinations may be associated to fluorescent in situ hybridization in all cases of fetal anomalies.

Original languageEnglish
Pages (from-to)467-469
Number of pages3
JournalClinical and Experimental Obstetrics and Gynecology
Volume43
Issue number3
DOIs
Publication statusPublished - 2016

Fingerprint

Nuchal Translucency Measurement
Ovarian Hyperstimulation Syndrome
Hydatidiform Mole
Trophoblasts
Fluorescence In Situ Hybridization
Legal Abortion
Chorionic Villi
Pregnancy
Prenatal Diagnosis
Gestational Age
Ultrasonography
Fetus
Embryonic Structures

Keywords

  • Diginyc mole
  • Fetal nuchal translucency
  • Ovarian hyperstimulation syndrome
  • Partial hydatidiform mole

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Diginyc partial hydatidiform mole with increased fetal nuchal translucency and ovarian hyperstimulation syndrome. / Gaggero, Chiara Roberta; Bogliolo, Stefano; Sala, Paolo; Molinari, C.; Motzo, S.; Fulcheri, Ezio; Anserini, Paola; De Biasio, Pierangela.

In: Clinical and Experimental Obstetrics and Gynecology, Vol. 43, No. 3, 2016, p. 467-469.

Research output: Contribution to journalArticle

Gaggero, Chiara Roberta ; Bogliolo, Stefano ; Sala, Paolo ; Molinari, C. ; Motzo, S. ; Fulcheri, Ezio ; Anserini, Paola ; De Biasio, Pierangela. / Diginyc partial hydatidiform mole with increased fetal nuchal translucency and ovarian hyperstimulation syndrome. In: Clinical and Experimental Obstetrics and Gynecology. 2016 ; Vol. 43, No. 3. pp. 467-469.
@article{b84e6a711bc441c0b4c8c11b8057c124,
title = "Diginyc partial hydatidiform mole with increased fetal nuchal translucency and ovarian hyperstimulation syndrome",
abstract = "Purpose of investigation: Hydatidiform mole (HM) is an abnormal pregnancy characterized by proliferation of cytotrophoblast and syncytiotrophoblast and vesicular swelling of placental villi. The fetus or embryo can be absent or abnormal. HMs can be complete or partial. Case Report: A case of diginyc partial HM at 12 weeks of gestational age was referred to the present center of prenatal diagnosis. The patient showed ovarian hyperstimulation syndrome. At ultrasonography, increased fetal nuchal translucency (NT) with fetal anomaly was evident, without sonographic signs of placental mole. Pregnancy was terminated with legal abortion. Results: Partial HM (PHM) was suspected by ultrasonographic fetal markers with ovarian hyperstimulation syndrome, but the diagnosis was performed only with fluorescent in situ hybridization. In particular fetal NT appeared increased also in diginyc mole. Conclusion: In order to improve the detection rate of PHM, routine histological examinations may be associated to fluorescent in situ hybridization in all cases of fetal anomalies.",
keywords = "Diginyc mole, Fetal nuchal translucency, Ovarian hyperstimulation syndrome, Partial hydatidiform mole",
author = "Gaggero, {Chiara Roberta} and Stefano Bogliolo and Paolo Sala and C. Molinari and S. Motzo and Ezio Fulcheri and Paola Anserini and {De Biasio}, Pierangela",
year = "2016",
doi = "10.12891/ceog2160.2016",
language = "English",
volume = "43",
pages = "467--469",
journal = "Clinical and Experimental Obstetrics and Gynecology",
issn = "0390-6663",
publisher = "S.O.G. CANADA Inc.",
number = "3",

}

TY - JOUR

T1 - Diginyc partial hydatidiform mole with increased fetal nuchal translucency and ovarian hyperstimulation syndrome

AU - Gaggero, Chiara Roberta

AU - Bogliolo, Stefano

AU - Sala, Paolo

AU - Molinari, C.

AU - Motzo, S.

AU - Fulcheri, Ezio

AU - Anserini, Paola

AU - De Biasio, Pierangela

PY - 2016

Y1 - 2016

N2 - Purpose of investigation: Hydatidiform mole (HM) is an abnormal pregnancy characterized by proliferation of cytotrophoblast and syncytiotrophoblast and vesicular swelling of placental villi. The fetus or embryo can be absent or abnormal. HMs can be complete or partial. Case Report: A case of diginyc partial HM at 12 weeks of gestational age was referred to the present center of prenatal diagnosis. The patient showed ovarian hyperstimulation syndrome. At ultrasonography, increased fetal nuchal translucency (NT) with fetal anomaly was evident, without sonographic signs of placental mole. Pregnancy was terminated with legal abortion. Results: Partial HM (PHM) was suspected by ultrasonographic fetal markers with ovarian hyperstimulation syndrome, but the diagnosis was performed only with fluorescent in situ hybridization. In particular fetal NT appeared increased also in diginyc mole. Conclusion: In order to improve the detection rate of PHM, routine histological examinations may be associated to fluorescent in situ hybridization in all cases of fetal anomalies.

AB - Purpose of investigation: Hydatidiform mole (HM) is an abnormal pregnancy characterized by proliferation of cytotrophoblast and syncytiotrophoblast and vesicular swelling of placental villi. The fetus or embryo can be absent or abnormal. HMs can be complete or partial. Case Report: A case of diginyc partial HM at 12 weeks of gestational age was referred to the present center of prenatal diagnosis. The patient showed ovarian hyperstimulation syndrome. At ultrasonography, increased fetal nuchal translucency (NT) with fetal anomaly was evident, without sonographic signs of placental mole. Pregnancy was terminated with legal abortion. Results: Partial HM (PHM) was suspected by ultrasonographic fetal markers with ovarian hyperstimulation syndrome, but the diagnosis was performed only with fluorescent in situ hybridization. In particular fetal NT appeared increased also in diginyc mole. Conclusion: In order to improve the detection rate of PHM, routine histological examinations may be associated to fluorescent in situ hybridization in all cases of fetal anomalies.

KW - Diginyc mole

KW - Fetal nuchal translucency

KW - Ovarian hyperstimulation syndrome

KW - Partial hydatidiform mole

UR - http://www.scopus.com/inward/record.url?scp=84975090038&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84975090038&partnerID=8YFLogxK

U2 - 10.12891/ceog2160.2016

DO - 10.12891/ceog2160.2016

M3 - Article

VL - 43

SP - 467

EP - 469

JO - Clinical and Experimental Obstetrics and Gynecology

JF - Clinical and Experimental Obstetrics and Gynecology

SN - 0390-6663

IS - 3

ER -