Digital breast tomosynthesis versus digital mammography: A clinical performance study

Gisella Gennaro, Alicia Toledano, Cosimo Di Maggio, Enrica Baldan, Elisabetta Bezzon, Manuela La Grassa, Luigi Pescarini, Ilaria Polico, Alessandro Proietti, Aida Toffoli, Pier Carlo Muzzio

Research output: Contribution to journalArticlepeer-review


Objective: To compare the clinical performance of digital breast tomosynthesis (DBT) with that of fullfield digital mammography (FFDM) in a diagnostic population. Methods: The study enrolled 200 consenting women who had at least one breast lesion discovered by mammography and/or ultrasound classified as doubtful or suspicious or probably malignant. They underwent tomosynthesis in one view [mediolateral oblique (MLO)] of both breasts at a dose comparable to that of standard screen-film mammography in two views [craniocaudal (CC) and MLO]. Images were rated by six breast radiologists using the BIRADS score. Ratings were compared with the truth established according to the standard of care and a multiple-reader multiplecase (MRMC) receiver-operating characteristic (ROC) analysis was performed. Clinical performance of DBTcompared with that of FFDMwas evaluated in terms of the difference between areas under ROC curves (AUCs) for BIRADS scores. Results: Overall clinical performance with DBT and FFDM for malignant versus all other cases was not significantly different (AUCs 0.851 vs 0.836, p=0.645). The lower limit of the 95% CI or the difference between DBT and FFDM AUCs was -4.9%. Conclusion: Clinical performance of tomosynthesis in one view at the same total dose as standard screen-film mammography is not inferior to digital mammography in two views.

Original languageEnglish
Pages (from-to)1545-1553
Number of pages9
JournalEuropean Radiology
Issue number7
Publication statusPublished - Jul 2010


  • Clinical performance.
  • Digital breast tomosynthesis.
  • Digital mammography.
  • Non-inferiority
  • ROC analysis.

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)


Dive into the research topics of 'Digital breast tomosynthesis versus digital mammography: A clinical performance study'. Together they form a unique fingerprint.

Cite this