Digital breast tomosynthesis versus digital mammography: A clinical performance study

Gisella Gennaro, Alicia Toledano, Cosimo Di Maggio, Enrica Baldan, Elisabetta Bezzon, Manuela La Grassa, Luigi Pescarini, Ilaria Polico, Alessandro Proietti, Aida Toffoli, Pier Carlo Muzzio

Research output: Contribution to journalArticle

Abstract

Objective: To compare the clinical performance of digital breast tomosynthesis (DBT) with that of fullfield digital mammography (FFDM) in a diagnostic population. Methods: The study enrolled 200 consenting women who had at least one breast lesion discovered by mammography and/or ultrasound classified as doubtful or suspicious or probably malignant. They underwent tomosynthesis in one view [mediolateral oblique (MLO)] of both breasts at a dose comparable to that of standard screen-film mammography in two views [craniocaudal (CC) and MLO]. Images were rated by six breast radiologists using the BIRADS score. Ratings were compared with the truth established according to the standard of care and a multiple-reader multiplecase (MRMC) receiver-operating characteristic (ROC) analysis was performed. Clinical performance of DBTcompared with that of FFDMwas evaluated in terms of the difference between areas under ROC curves (AUCs) for BIRADS scores. Results: Overall clinical performance with DBT and FFDM for malignant versus all other cases was not significantly different (AUCs 0.851 vs 0.836, p=0.645). The lower limit of the 95% CI or the difference between DBT and FFDM AUCs was -4.9%. Conclusion: Clinical performance of tomosynthesis in one view at the same total dose as standard screen-film mammography is not inferior to digital mammography in two views.

Original languageEnglish
Pages (from-to)1545-1553
Number of pages9
JournalEuropean Radiology
Volume20
Issue number7
DOIs
Publication statusPublished - Jul 2010

Keywords

  • Clinical performance.
  • Digital breast tomosynthesis.
  • Digital mammography.
  • Non-inferiority
  • ROC analysis.

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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    Gennaro, G., Toledano, A., Di Maggio, C., Baldan, E., Bezzon, E., La Grassa, M., Pescarini, L., Polico, I., Proietti, A., Toffoli, A., & Muzzio, P. C. (2010). Digital breast tomosynthesis versus digital mammography: A clinical performance study. European Radiology, 20(7), 1545-1553. https://doi.org/10.1007/s00330-009-1699-5