Digital ulcers predict a worse disease course in patients with systemic sclerosis

Carina Mihai, R. Landewé, D. Van Der Heijde, Ulrich A. Walker, Paul I. Constantin, Ana Maria Gherghe, Ruxandra Maria Ionescu, Simona Rednic, Yannick Allanore, Jérôme Avouac, László Czirják, E. Hachulla, Gabriela Riemekasten, Franco Cozzi, Paolo Airo, Maurizio Cutolo, Ulf Mueller-Ladner, Marco Matucci-Cerinic, David Launay, Rucsandra DobrotaRoxana Sfrent-Cornateanu, Stefania Zingarelli, Erika Pigatto, Giovanna Cuomo, Paola Caramaschi, Lidia P. Ananieva, Susanne Ullman, Line Iversen, Alexandra Balbir Gurman, Yolanda Braun-Moscovici, Patricia Carreira, Beatriz Joven, Tünde Minier, Serena Guiducci, Silvia Bellando-Randone, Raffaele Pellerito, Nicolas Hunzelmann, Ingo H. Tarner, Sebastião Cezar Radominski, Carolina De Souza Müller, Florenzo Iannone, Jörg Henes, Dominique Farge Bancel, Nemanja Damjanov, Predrag Ostojic, Maria R. Pozzi, Roger Hesselstrand, Christopher Denton, Dorota Krasowska, Mohammed Tikly, Valeria Riccieri, F. Cantatore, Ada Corrado, José Antonio Pereira Da Silva, Maria João Salvador, Alan Tyndall, Armando Gabrielli, Oliver Distler, Suzan Jordan, Stefan Heitmann, Harald Burkhardt, Andrea Himsel, Blaz Rozman, Vanessa Smith, Filip De Keyser, Dusanka Martinovic Kalitena, Mislav Radic, Ileana Filipescu, Ana Petcu, Panayiotis G. Vlachoyiannopoulos, Eugene Kucharz, Malgorzata Widuchowska, Magdalena Kopec-Medrek, Anna Kotulska, Gabriella Szücs, Aleksandra Stankovic, Bojana Stamenkovic, Carlo Francesco Selmi, Maria De Santis, Bianca Marasini, Bernard Coleiro, Vera Ortiz Santamaria, Rene Westhovens, Radim Becvar, Srdan Novak, Merete Engelhart, Pier Luigi Meroni, Francesca Ingegnoli, Silvana Zeni, Alberto Sulli, Jörg H W Distler, Sule Kurhan Yavuz, Carlomaurizio Montecucco, Kilian Eyerich, Brigitte Krummel-Lorenz, Thierry Zenone, Øyvind Midtvedt, Carlo Chizzolini, Matthias Seidel, Mara Oleszowsky, Maria Üprus, Daniela Opris, Laura Groseanu, Otylia Kowal Bielecka, Zea Mendoza Antonio, Jacek Szechinski, Jadranka Morovic-Vergles, Raffaella Scorza, Francesco Puppo, A. Mathieu, Branimir Anic, J. Stork, Simon Stebbings, M. Inanc, Paul Hasler, Carlos A. Von Mühlen, Martin Aringer, Sergei Popa, Mengtao Li, Edoardo Rosato

Research output: Contribution to journalArticle

Abstract

Objective: Systemic sclerosis (SSc) is a systemic autoimmune disease with high morbidity and significant mortality. There is a great need of predictors that would allow risk stratification of patients with SSc and ultimately initiation of treatment early enough to ensure optimal clinical results. In this study, we evaluated whether a history of digital ulcers (HDU) at presentation may be a predictor of vascular outcomes and of overall clinical worsening and death in patients with SSc. Methods: Patients from the EULAR Scleroderma Trials and Research (EUSTAR) database, satisfying at inclusion the 1980 American College of Rheumatology classification criteria for SSc, who had a follow-up of at least 3 years since baseline or who have died, were included in the analysis. HDU at presentation as a predictor of disease worsening or death was evaluated by Cox proportional hazards regression analysis. Results :3196 patients matched the inclusion criteria (male sex 13.2%, 33.4% diffuse subset). At presentation, 1092/3196 patients had an HDU (34.1%). In multivariable analysis adjusting for age, gender and all parameters considered potentially significant, HDU was predictive for the presence of active digital ulcers (DUs) at prospective visits (HR (95% CI)): 2.41(1.91 to 3.03), p

Original languageEnglish
Pages (from-to)681-686
Number of pages6
JournalAnnals of the Rheumatic Diseases
Volume75
Issue number4
DOIs
Publication statusPublished - Apr 1 2016

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy

Fingerprint Dive into the research topics of 'Digital ulcers predict a worse disease course in patients with systemic sclerosis'. Together they form a unique fingerprint.

  • Cite this

    Mihai, C., Landewé, R., Van Der Heijde, D., Walker, U. A., Constantin, P. I., Gherghe, A. M., Ionescu, R. M., Rednic, S., Allanore, Y., Avouac, J., Czirják, L., Hachulla, E., Riemekasten, G., Cozzi, F., Airo, P., Cutolo, M., Mueller-Ladner, U., Matucci-Cerinic, M., Launay, D., ... Rosato, E. (2016). Digital ulcers predict a worse disease course in patients with systemic sclerosis. Annals of the Rheumatic Diseases, 75(4), 681-686. https://doi.org/10.1136/annrheumdis-2014-205897