Digoxin use and lower 30-day all-cause readmission for medicare beneficiaries hospitalized for heart failure

Ali Ahmed, Robert C. Bourge, Gregg C. Fonarow, Kanan Patel, Charity J. Morgan, Jerome L. Fleg, Inmaculada B. Aban, Thomas E. Love, Clyde W. Yancy, Prakash Deedwania, Dirk J. Van Veldhuisen, Gerasimos S. Filippatos, Stefan D. Anker, Richard M. Allman

Research output: Contribution to journalArticlepeer-review


Background: Heart failure is the leading cause for hospital readmission, the reduction of which is a priority under the Affordable Care Act. Digoxin reduces 30-day all-cause hospital admission in chronic systolic heart failure. Whether digoxin is effective in reducing readmission after hospitalization for acute decompensation remains unknown. Methods: Of the 5153 Medicare beneficiaries hospitalized for acute heart failure and not receiving digoxin, 1054 (20%) received new discharge prescriptions for digoxin. Propensity scores for digoxin use, estimated for each of the 5153 patients, were used to assemble a matched cohort of 1842 (921 pairs) patients (mean age, 76 years; 56% women; 25% African American) receiving and not receiving digoxin, who were balanced on 55 baseline characteristics. Results: Thirty-day all-cause readmission occurred in 17% and 22% of matched patients receiving and not receiving digoxin, respectively (hazard ratio [HR] for digoxin, 0.77; 95% confidence interval [CI], 0.63-0.95). This beneficial association was observed only in those with ejection fraction

Original languageEnglish
Pages (from-to)61-70
Number of pages10
JournalAmerican Journal of Medicine
Issue number1
Publication statusPublished - Jan 2014


  • Digoxin
  • Heart failure
  • Hospital readmission

ASJC Scopus subject areas

  • Medicine(all)


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