Dihydroergocriptine in Parkinson's disease: Clinical efficacy and comparison with other dopamine agonists

A. Albanese, Carlo Colosimo

Research output: Contribution to journalArticle

Abstract

The present paper reviews clinical studies on the use of dihydroergocriptine (DHEC), an ergot derivative with dopamine agonist activity, for the treatment of Parkinson's disease. This compound is a hydrogenated ergot derivative structurally quite similar to bromocriptine, from which it differs because of the hydrogenation in C9-C10 and the lack of bromine in C2. DHEC has a potent D2-1ike receptor agonist and a partial D1-like receptor agonist activity; because of this biochemical profile, it has been suggested that DHEC may produce fewer side-effects and have clinical efficacy equal to that of a classical dopamine agonist. Several open-label and double-blind studies indicate that DHEC is an efficacious remedy for parkinsonian signs and symptoms. Further studies are necessary to compare DHEC to new dopamine agonists (pergolide, cabergoline, ropinirole, and pramipexole) which have been more recently marketed.

Original languageEnglish
Pages (from-to)349-355
Number of pages7
JournalActa Neurologica Scandinavica
Volume107
Issue number5
DOIs
Publication statusPublished - May 1 2003

    Fingerprint

Keywords

  • Clinical trials
  • Dopamine agonists
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this