Dihydroergotoxine decreases blood pressure in spontaneously hypertensive rats by interacting with peripheral dopamine receptors

Maurizio Memo, Giovanni Sagheddu, Michele O. Carruba, PierFranco Spano

Research output: Contribution to journalArticle

Abstract

Dihydroergotoxine (10 μg/kg s.c.) decreased mean carotid blood pressure in urethane-anaesthetized spontaneously hypertensive rats but failed to modify the same parameter in normotensive rats. The effect was statistically significant 20 min after the injection and relatively long lasting (up to 90 min). Pharmacological characterization of the phenomenon indicated that it is mediated by stimulation of dopamine receptors, since pretreatment with haloperidol, cis-flupentixol but not with trans-flupentixol, completely prevent the reduction in blood pressure induced by dihydroergotoxine. Moreover, a challenge dose of dihydroergotoxine did not reduce mean blood pressure values in spontaneously hypertensive rats pretreated with domperidone or (-)sulpiride, but not with (+) sulpiride. These results suggest that the ergot derivative modifies the cardiovascular system by interaction with peripheral dopamine receptors of the DA2 type.

Original languageEnglish
Pages (from-to)1515-1522
Number of pages8
JournalLife Sciences
Volume36
Issue number16
DOIs
Publication statusPublished - Apr 22 1985

ASJC Scopus subject areas

  • Pharmacology

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